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Private costs almost equal health care costs when intervening in mild Alzheimer's: a cohort study alongside the DAISY trial
© Søgaard et al; licensee BioMed Central Ltd. 2009
Received: 20 March 2009
Accepted: 25 November 2009
Published: 25 November 2009
Alzheimer's disease is the leading cause of dementia and affects about 25 million people worldwide. Recent studies have evaluated the effect of early interventions for dementia, but few studies have considered private time and transportation costs associated with the intervention. This study assessed the total economic costs associated with a multifaceted intervention for mild Alzheimer's disease, including an estimate of the ratio of public to private costs.
The study sample comprised 163 dyads of patients and caregivers who received a multifaceted intervention of counselling sessions, courses and informational packages. The typical duration of the intervention was 7 months. A micro-costing approach was applied using prospectively collected data on resource utilisation that included estimates of participant time and transportation. Precision estimates were calculated using a bootstrapping technique and structural uncertainty was assessed with sensitivity analysis.
The direct intervention cost was estimated at EUR 1,070 (95% CI 1,029;1,109). The total cost (including private costs) was estimated at EUR 2,020 (95% CI 1,929;2,106) i.e. the ratio of private to public costs was almost 1:1.
Intervention for mild Alzheimer's disease can be undertaken at a relatively low cost to public funds. However, policy planners should pay attention to the significant private costs associated with an intervention, which may ultimately pose a threat to equity in access to health care.
Current Controlled Trials ISRCTN74848736.
Recent estimates suggest that 24.3 million people worldwide have dementia and that every year 4.6 million new cases occur . The prevalence of dementia has thus been significantly underestimated and its incidence will increase in the coming years due to demographic shift . Alzheimer's disease (AD) is the leading cause of dementia, accounting for more than half of the cases .
The cost of care for people with dementia, sometimes divided into the cost of formal care and that of informal care, is related to the stage of disease. The UK combined annual 2005/6 costs for people with dementia living in the community were estimated at £16,689, £25,877 and £37,473 per person for mild, moderate and severe dementia, respectively . US estimates are generally higher but, due to methodological differences, wide variation is demonstrated across studies [5, 6]. None of these studies included valuation of reduced quality of life experienced by the person with dementia or the caregiver, i.e. cost estimates represent minimum values.
Dementia is a chronic condition and intervention typically aims at slowing down disease progress and improving quality of life for the person with dementia. However, dementia affects not only the patient but also the caregivers, who are often family members or others close to the patient . The gradual loss of the patient's cognitive ability exerts a significant emotional strain on the caregiver, and this can have implications for the caregiver's social or working life [6, 8]. From both clinical and health economic perspectives, therefore, it is important that interventions for dementia take into account effects on caregivers.
The rationale for early intervention in dementia is clear, but there is no apparent gold standard for the most appropriate approach. Current proposals include training and education programmes, information and technology-based support including specialised computer and telephone networks, and more formal approaches to planning care . Some of these have been assessed for economic efficiency and found to be cost effective [10–13] but none have included the resource category of participant time, i.e. the time required from participants to attend therapeutic regimens. This need not be vital when providing decision-makers with a foundation for prioritizing resources under the objective of allocative efficiency but, when prioritizing resources under the additional objective of equity in access to care, the burden of private costs becomes highly relevant .
Even in a publicly financed health care system, users are faced with copayment due to transportation costs, out-of-pocket costs and the opportunity cost of their time spent receiving therapy. These costs, ceteris paribus, increase with the duration and intensity of a therapeutic regimen and are further increased if the regimen is targeted to multiple parties e.g. patients and caregivers. Costs to private parties associated with interventions for mild AD thus pose a challenge to health policy planning in that the implementation of new interventions may have detrimental effects on equity; less resourceful patients or caregivers may decline participation due to excessive private costs or, if accepting therapy, they may experience significant financial strain. This consequence has been neglected in the AD literature .
This paper assesses intervention costs of a best-bet-intervention in mild AD using a micro-costing approach to facilitate precise estimation of public and private costs. It should not be confused with the literature assessing the extent or interrelationship of formal and informal costs. This study takes a narrower view of the extent of copayment in a population that is particularly vulnerable due to the nature of the therapeutic regimen - which is often long term and requires time and input from caregivers. The aim of this study was to assess the total economic costs of a multifaceted intervention in mild AD, as well as the ratio of public to private costs.
Sample and study design
The study sample of 163 dyads of patients and their caregivers was selected from a multi-centre, randomised, controlled trial examining the efficacy of multifaceted intervention aimed at patients and their caregivers. The study sample included participants assigned to the intervention arm only, as the control group received no intervention. The trial was conducted across five (out of 15) Danish county districts. Inclusion criteria comprised age ≥ 50 years, a recent diagnosis of AD (within the past 12 months), Mini Mental State Examination (MMSE) score ≥ 20, and having a primary caregiver who was willing to participate in the study. The diagnosis of dementia was determined in consensus with fourth edition of the The Diagnostic and Statistical Manual of Mental Disorders  and the subtype of AD was determined using the NINCDS-ADRDA criteria . Exclusion of patients with Lewy body disease was based on the McKeith criteria . Furthermore, institutionalised patients and patients with severe comorbidity were excluded. The present study is thus a cohort study following persons with AD and their caregivers from the first contact they had as part of the intervention (initial meeting) to the last follow-up (final meeting), which typically took place six to twelve months after the initial meeting. The first study patients presented in January 2004 and the final follow-up visit was in June 2006.
A multifaceted intervention was designed with the objective of preventing or reducing depressive symptoms, impairments of health-related quality of life and loss of social network. The philosophy was to focus on positive resources, intact functions and retained skills, and activities that patients could still participate in. The following sections describe key components of the intervention.
A series of five counselling sessions, comprising both individual sessions and group participation, was scheduled. Counselling was based on constructivist principles  and supported by the use of written notes, that were established at the initial meeting and used to focus follow-up sessions, according to Ishiayma's ideas on self-validation . A designated nurse undertook all counselling sessions after receiving specialised training in the constructivist approach. In addition to face-to-face time, the counsellor had an average preparation time of 30 minutes before an initial meeting and 10 minutes before a follow-up meeting. Participating study centres decided individually whether counselling was undertaken in the patient's home or at the centre; approximately one-third of the sessions took place in the patients' homes.
Two parallel lines, each of five courses, were aimed at patients and caregivers, respectively. The objective was to provide basic knowledge about dementia and its consequences as well as to establish a forum for patients and caregivers to exchange experiences and coping strategies. Patient-targeted courses included written and oral information on key issues about dementia and its consequences. Caregiver-targeted courses included more formal education about AD, supplemented by written information. All courses were scheduled for 12 participants per session and were run by one counsellor and one invited teacher. Patient-targeted courses were additionally staffed by two volunteers, who assisted the professionals during the courses. Course duration was fixed at two hours (with an additional 30 minutes of preparation time for the counsellor).
At inclusion into the study, patients and caregivers were informed that the intervention would include a regular telephone call from the counsellor (approximately five to eight times in intervals of three to four weeks) to ensure regular contact and to follow up on issues discussed in individual counselling sessions. Patients and caregivers were asked to decide who should receive the telephone calls; this could be either or both parties.
Handbook and Logbook
A comprehensive handbook about dementia was composed for the study; one part was targeted patients and the other caregivers. The handbook contained chapters on causes of dementia, legal aspects in relation to living with dementia, and sources and contacts for social support. The handbook included a logbook section to encourage patients and caregivers to write about their daily lives and activities. However, since only six patients and seven caregivers did so, this information was not included in the present analysis.
The intervention comprised a range of components that participants could choose to take advantage of. Participation was thus a result of the counsellor's assessment of individual needs and preferences in collaboration with the participant's (patient, caregiver, network) wishes. The term 'compliance' was thus avoided and replaced by the term 'concordance' to emphasise that target participation rates were not necessarily 1.00. Concordance is typically defined as adherence to an agreed schedule rather than adherence to a fixed regimen.
The intervention was costed from a societal perspective, including the costs of both formal and informal time of the persons involved, and based on concurrent data collection on resource utilisation.
The costs of developing or implementing the intervention were not included in the present analysis, which should be seen as estimating long-term average costs of implementing the intervention in routine practice. As the intervention was designed as a flexible framework from which a tailored course could be set for each dyad, the cost analysis was conducted as a per-protocol analysis with service utilisation counting only if it did in fact occur.
A case report form - administered by the counsellor - was used to register the time (minutes) spent by professional staff, the patient, the caregiver and the patient's network across the scheduled activities of the intervention: counselling, telephone counselling and courses. A load-factor of 1.56 was applied to the cost of counselling to account for non-productive time, i.e. effective confrontation time was assumed to amount to, on average, 45 minutes of an hour (load of 0.25) due to pauses, walking distance between locations, private time etc. The remainder load (0.31) was based on internal statistics on absence from work due to vacation, sickness etc.
Valuation of formal care was based on gross market wage rates from national collective agreements between Danish local government and the respective professional associations except for teaching activity at courses, which was valued using market prices. An overhead rate of 20% was applied to account for capital costs.
Item costs used for estimating the costs of a support programme for mild Alzheimer's disease.
Time costs of formal care
Counsellor (specially trained nurse)
Local Government Denmark [KL]
Load-factor for counsellor's time [weight]1
Local Government Denmark [KL]/estimate
Course teacher, nurse [per course]
Market prices (tariff of trial management)
Course teacher, academic [per course]
Market prices (tariff of trial management)
Volunteers assisting course personnel
National average net salary for 50-year olds
Local Government Denmark [KL]
Time costs of informal time (examples)2
Male, 50-54 years, gross
Male, 50-54 years, net
Female, 50-54, gross
Female, 50-54, net
Transportation cost professionals [EUR/km]
Transportation cost participant [EUR/km]
Baseline characteristics of patients and caregivers were described using conventional parametric statistics and simple frequencies with percentage proportions. All other reported estimates are arithmetic means with 95% bias-corrected, bootstrapped confidence intervals (95% CIs) from a non-parametric bootstrap distribution, which was estimated from 1,000 extract replications from the original sample (n = 163). The technique of bootstrapping is a resampling technique that is appropriate for estimating confidence intervals in the presence of e.g. positively skewed data . Statistical analyses were conducted using STATA version 10.0 (StataCorp, Texas).
The trial was conducted in accordance with the Helsinki declaration and was approved by the local ethics committee. All patients and caregivers provided written informed consent.
A total of 163 dyads were included, but only 157 dyads received the intervention; three dyads dropped out due to the intervention being too demanding for caregivers, one dyad dropped out due to the intervention being too demanding for the patient, one dyad dropped out because the patient was hospitalised due to comorbidity, and one dyad dropped out because the patient died before the intervention started.
Baseline characteristics of the study population of patients with mild Alzheimer's disease and their primary caregiver.
Patient (n = 157)
Caregiver (n = 157)
Age, mean (SD)
Females, n (%)
Living alone (%)
MMSE score, mean (SD)
EQ-5D score (self-assessed), mean (SD)
Occupational status, n (%)
On early retirement
Other (e.g. housewife)
Caregiver's relation to patient, n (%)
Rates of participation (95% confidence intervals) in a flexible, multifaceted intervention for mild Alzheimer's disease.
(n = 157)
(n = 157)
(n = 157)
1st follow-up meeting
2nd follow-up meeting
Participated in at least 3 counsellings3
Participated in at least 3 courses3
Mean duration of intervention (days)
Resource utilisation by health care personnel, patients, caregivers, and patient networks in a multifaceted intervention for mild Alzheimer's disease.
(n = 157)
(n = 157)
(n = 157)
While all courses could accommodate up to 12 participants, for logistic reasons most courses were conducted with fewer participants. The variation in professional time used was thus due to variation in the number of participants (class size) rather than variation in course duration. Overall, the course activity used nine hours of professional time, associated with an average of almost eight hours of face-to-face time for patients and caregivers.
The resource utilisation associated with transportation reflects non-productive professional and participant time. The majority of counselling sessions (two-thirds) were held at health care institutions; hence the greatest transportation burden was on the patients and caregivers, who each spent an average of almost eight hours on transportation between their homes and the institution. Professionals had an average transportation burden of about four hours, which was attributable to the one-third of counselling sessions that were conducted in patients' own homes.
Altogether, the resource utilisation associated with the intervention amounted to 19-21 hours each for the professionals, patients and caregivers, and 6 hours for the network contacts.
Intervention costs of multifaceted intervention for mild Alzheimer's disease.
Indirect costs (time costs)
(n = 157)
(n = 157)
(n = 157)
It can be argued that patient time should be valued using a wage rate less than that of fully productive individuals. The average impact of valuing patient time using a fixed rate of EUR 5 per hour was a total cost reduction of EUR 142 per dyad and a copayment rate reduction of 0.04. The average impact of increasing (or reducing) the overhead rate by 15% was an extra (or reduced) cost of EUR 95 per dyad, which would affect the copayment rate by -0.02 (+0.02). Finally, the impact of transportation costs was analysed as these may vary considerably across settings due to e.g. population density and degree of specialisation of health care institution. Had the average one-way distance (and time used on transportation) been doubled, average participant costs would increase by EUR 511 per dyad and the copayment rate would increase by 0.11.
This paper reports the economic consequences to both private and public funds of a best-bet intervention aimed at patients with mild AD and their primary caregivers. The intention of this work was to examine the extent to which long-standing intervention involving not only patients but also caregivers requires direct and indirect copayment, which ultimately may affect equity in access to health care. The main finding was that intervention in mild AD may come at a relatively low cost to public funds but, at the same time, it requires significant copayment from private parties, which can be summarised in a cost-sharing ratio between private and public pockets of almost 1:1.
The concurrent and detailed measurement of patient and caregiver time required for the successful intervention in mild AD could have been performed in other intervention studies, yet this seems to have been neglected in studies reported in the literature. This is in contrast to a strong economic theoretical recommendation to include patient and caregiver time as essential resource utilisations: costing from a societal perspective should include all resource utilisation irrespective of who invests it. The absence of such practice could be due to a lack of consensus regarding a valid and reliable framework for costing informal care [23–25] or to the more pragmatic issue of whether the required effort of measurement is worthwhile relative to the benefit.
From a theoretical point of view, a patient is 'occupied' when he or she is receiving treatment and thus benefits are sacrificed elsewhere i.e. the person cannot gain utility from leisure time or financial earnings (if in paid employment). The minimum value of benefits forgone is, using the opportunity cost approach, approximated by the individual's net (if leisure time is used) or gross wage (if time off from work is used) . However, as most AD patients are not in paid work, a hypothetical wage rate (we used the age- and gender-matched national average) may not reflect the true value of patients' time. We conducted sensitivity analysis using a lower rate, in order to be flexible about using the average wage rate to value patient time. However, only a moderate impact on the overall cost-sharing ratio was demonstrated.
The term 'concordance' was used instead of the more conventional term 'compliance'. This was in consensus with recent criticism that 'compliance' denotes the extent to which the patient obeys the clinician rather than takes an active role in the doctor-patient relationship [27, 28]. In this context, concordance refers to the extent to which the collaboration between counsellor and participant results in participation in individual components of the intervention. Relating to external validity, the high rates of participation achieved in the current trial were higher than expected and may be explained by the fact that participants seemed to be socioeconomically advantaged relative to the average citizen and, not least, that the trial was undertaken by highly dedicated professional staff. Lower rates of participation may be expected in routine practice, although that would not be expected to significantly influence the ratio of private to public costs.
There are some uncertain variables in relation to local infrastructure - both of the health care sector (e.g. whether relevant professionals are available at the nearest institution) and the private sector (e.g. what is the average distance from participants' homes to the institution). We observed significant variation across the five county districts of the trial, partly due to the free choice of participating centres to conduct counselling in the patients' homes or at health care institutions. Similarly, some centres were able to run highly efficient courses with all places filled, while others suffered low volume due to location in rural areas. Such variation affects not only total intervention costs but also shifts costs back and forth between private and public pockets.
Several issues are of note for community health planners who might consider adaptation of the intervention described here. First, the study population represents a relatively resourceful group as they are at an early disease stage and are socioeconomically advantaged. While the study is one of the few to describe an intervention targeted to this population, the results are not likely to be generalisable to more severe stages of AD. Second, favourable resource utilisation and costs are irrelevant if there is no evidence for a clinical effect and the most useful approach would be a synthesis of information as a cost-effectiveness evaluation. These analyses are currently in progress. A third remark relates to budget impact, which should be estimated by multiplying not only the n of a target population with the intervention cost, but should also take into account that a certain proportion of eligible dyads reject the invitation to participate and a further proportion drop out after initially agreeing to participate. We have no estimates on the former proportion, whereas the latter appeared to be 0.12. Consideration should also be given to recruitment of participants, that is, whether existing regimens can accommodate recruitment or whether extra resources are required to establish a regimen for screening and inviting candidate participants. Such costs are not included in the present analysis. Finally, start-up costs of e.g. recruiting and educating staff, developing informational packages etc. should be expected (these were not included in the current study).
It has long been argued that disparities in the use and quality of care are particularly evident in long-term care, but the first attempt to summarise this evidence was reported only recently . Much of the evidence arises from the USA and focuses on racial disparities, where Blacks generally appear to have a lower health care use than Hispanics. One study, however, shows that individuals with low socioeconomic status generally underuse health care; explanatory variables appear to include organisational and geographic characteristics of care provision . This could be synonymous with a hypothesis that requirements of considerable participant time input and high transportation costs pose a restriction to health care access. However, the direct question of whether a 1:1 cost-sharing ratio between private and public finances restricts access to care for some groups relative to others remains unanswered.
Intervention in mild Alzheimer's disease can be undertaken at a relatively low cost to public funds. However, policy planners should pay attention to the significant private costs associated with an intervention, which may ultimately pose a threat to equity in access to health care.
We would like to thank the 128 volunteers and assistants from the 68 municipalities and 5 counties, as well as the following project coordinators and physicians in the 5 participating centres, for their contributions to patient recruitment, intervention, and data collection: Ribe County: Esbjerg Hospital, Department of Psychiatry (Anna Marie Hansen, Johanne Christensen, Jørgen Jensen). Ringkoebing County: Herning Hospital, Department of Psychiatry (Marianne Refslund, Birgitte Aagaard, Palle Lund) and Holstebro Hospital, Department of Psychiatry (Inge Lund Petersen, Finn Andersen). Roskilde County: Roskilde Hospital, Department of Geriatrics (Dorte Dyre, Lisbeth Petersen, Birgitte Froelund, Lise Korbo, Ellen Holm) and Department of Neurology (Kurt Luedorff). Vestsjaelland County: Korsoer Hospital, Department of Geriatrics (Mette Lassen, Lars Laugesen) and Dianalund hospital, Department of Psychiatry (Thyge Jensen, Ole Bjoern Skausig). Copenhagen Capital area: Hvidovre Hospital, Department of Geriatrics (Lillian Moerk Joergensen), Amager Hospital, Department of Geriatrics (Suzanne Sanders), Bispebjerg Hospital, Department of Geriatrics (Claus Moe), Frederiksberg Community Health Care Center (Ingrid Lauridsen), Frederiksberg Hospital, Department of Psychiatry (Rene Klysner), Glostrup Hospital, Department of Neurology, (Jens Feilberg), Rigshospitalet, Department of Neurology (Ane Eckerman, Eva Illemann, Susanne Rishoej, Lisbeth Villemoes Soerensen, Peter Johannsen). Finally, we would like to thank Medical Writer, Claire Margaret Gudex, for copyediting the final manuscript.
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