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Table 3 Sensitivity analysis of variables contributing to the costs of drug-related morbidity and mortality model

From: Health care use and costs of adverse drug events emerging from outpatient treatment in Germany: A modelling approach

  Sensitivity analyses Limit Description of rate used* Resulting Parameter Size Resulting ADEs (thousands) Resulting costs of ADEs (million €)
1. Comparison of effect of German hospitalisation rates on model Lower (base case) Schneeweiss [8]: 2.4% of medical admissions Hospitalisations**: 139,405 2,140 816
   Upper Dormann [7] : 3.8% of medical admissions Hospitalisations: 3,388 1,292
     Total: 220,724   
     (Death: 4,684)   
2. Variation in rate of physician visits according to literature*** Lower 3.5% [28] (total = 1,731,649) Physician visits: 635,008 2,375 828
     Additional treatment: 1,096,640   
   Upper 22% [29] (total = 11,075,753) Physician visits: 4,061,560 11,719 1,291
     Additional treatment: 7,014,193   
3. Variation in emergency department visits according to literature Lower 0.9% [28] 432,912 2,364 914
   Upper 3.0% [29] 1,499,696 3,431 1,380
4. Change in only hospital admissions according to literature Lower 0.5% [28] Hospitalisations: 246,603 2,252 1,205
     Deaths: 5346   
   Upper 4.2% [29] Hospitalisations: 2,051,109 4,096 7,569
     Deaths: 44,466   
  1. *Rates refer to percentage of patients taking medications unless stated otherwise; **Equal to base case calculations; ***1/3 calculated as only physician visit and 2/3 rds with additional treatment)