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Is there a gap between recommended and ‘real world’ practice in the management of depression in young people? A medical file audit of practice
© Hetrick et al.; licensee BioMed Central Ltd. 2012
Received: 14 December 2011
Accepted: 27 June 2012
Published: 27 June 2012
Literature has shown that dissemination of guidelines alone is insufficient to ensure that guideline recommendations are incorporated into every day clinical practice.
We aimed to investigate the gaps between guideline recommendations and clinical practice in the management of young people with depression by undertaking an audit of medical files in a catchment area public mental health service for 15 to 25 year olds in Melbourne, Australia.
The results showed that the assessment and recording of depression severity to ensure appropriate treatment planning was not systematic nor consistent; that the majority of young people (74.5%) were prescribed an antidepressant before an adequate trial of psychotherapy was undertaken and that less than 50% were monitored for depression symptom improvement and antidepressant treatment emergent suicide related behaviours (35% and 30% respectively). Encouragingly 92% of first line prescriptions for those aged 18 years or under who were previously antidepressant-naïve was for fluoxetine as recommended.
This research has highlighted the need for targeted strategies to ensure effective implementation. These strategies might include practice system tools that allow for systematic monitoring of depression symptoms and adverse side effects, particularly suicide related behaviours. Additionally, youth specific psychotherapy that incorporates the most effective components for this age group, delivered in a youth friendly way would likely aid effective implementation of guideline recommendations for engagement in an adequate trial of psychotherapy before medication is initiated.
A range of guidelines exist for depression in young people, including US guidelines for primary care  and the practice parameters of the American Academy of Child and Adolescent Psychiatry (AACAP)  UK guidelines  and most recently an Australian guideline . Key recommendations are consistent across these, advocating sequencing of interventions from low intensity for mild presentations to more intensive psychotherapy for moderate to severe presentations, with medication (fluoxetine first line) considered if necessary; and in this case close monitoring, particularly for emergent suicidality. However, it is widely recognized that implementation of guideline recommendations into every day clinical practice is far from universal  due to barriers at levels: 1. the individual clinician (e.g. knowledge, skills, attitudes); 2. the social context in which the clinician works (e.g. patients, colleagues, authorities); and 3. the organizational context (e.g. resources, organizational climate) . Failure to implement recommendations can result in inappropriate, unnecessary or harmful healthcare provision . For youth depression, as well as endeavoring to ensure recovery, the recommendations are critical in addressing safety concerns about antidepressant medication for this age group.
US research based on data submitted to the Food and Drug Administration (FDA) has shown those up to the age of 25 treated with antidepressant medication are more likely to experience an increase in suicidal ideation and suicide attempts [8–10] resulting in controversy about what constitutes optimal treatment for youth depression [11–14]. We sought to identify the impact of this on clinicians’ implementation of guideline recommendations in a public youth mental health service. In an initial study , we identified potential barriers to implementing these recommendations, including clinician beliefs that the recommendations were not relevant to young people presenting to the service, due to the severity and complexity of presentations with clinicians believing medication was warranted earlier than recommended, and that delivery of psychotherapy was difficult. Barriers also existed to undertaking regular monitoring of young people prescribed medication, including a lack of doctors, a perceived lack of expertise of case managers, and lack of time for systematic monitoring resulting in reliance on a passive approach, dependent on client spontaneous report . Our results were consistent with a US study concluding clinicians wanted more emphasis on the therapeutic relationship, and greater flexibility in implementing guideline recommendations .
In this second study, we sought to examine actual practice. On the basis of the findings above we hypothesised that ‘real-world’ practice, while broadly in line with guideline recommendations, might require improvements in some areas. At the time of the study, the Australian guidelines did not exist, therefore, we chose the U.K. NICE guidelines  as exemplars of the recommendations made in guidelines internationally.
That the clinician establishes depressive disorder symptom severity
That young people are offered medication if the (moderate to severe) depression is unresponsive after receiving four to six sessions of psychological therapy
That the first medication offered is fluoxetine
That careful monitoring of emergent suicidality and general progress (interpreted in this study as improvement of depression symptoms) take place once fluoxetine is prescribed, operationalized as once a week for four weeks.
The purpose of the research was to investigate these specific behaviours with the aim to ascertain gaps between guideline recommendations and clinical practice in the management of young people with depression in a public mental health setting.
Setting and sample
In Australia, public mental health services provide free mental health care for those with serious mental disorders. Our study took place at Orygen Youth Health (OYH); a public mental health service for young people aged 15-24 living in the northwestern metropolitan area of Melbourne, Australia. OYH receives referrals from primary services (e.g. general practitioners) and secondary services (e.g. pediatricians), although any referrals are considered, including direct referrals from young people, their caregivers, or places such as education settings. The Youth Access Team (YAT) receives these referrals, undertakes assessment and allocates young people to a clinical program. The clinical programs included the Personal Assessment and Crisis Evaluation (PACE) team for those at high risk of developing a psychotic disorder, the Early Psychosis Prevention and Intervention Clinic (EPPIC) for first episode psychosis, the Youth Mood Clinic (YMC) for moderate/severe depression, the Helping Young People Early (HYPE) clinic for emerging borderline personality disorder, the Intensive Mobile Youth Outreach Service (IMYOS) for outreach treatment to enhance engagement, and the service specific Inpatient Unit (IPU).
The study aimed to collect data from 150 consecutive clients who met the following inclusion criteria: they entered a clinical program at OYH for the first time between 1 April and 30 September 2007; they had a diagnosis of depressive disorder (DD), or had been prescribed antidepressants or antipsychotics (the latter included to ensure prescription of this class of medication for depressive disorder was captured) at least once in the first six months from the date of first presentation at OYH (the ‘audit period’).
DD was defined as Depressive Disorder NOS, Major Depressive Disorder Single or Recurrent of any level of severity, with or without psychotic features, or where ‘Depressive Disorder’ or ‘MDE’ or ‘Depression’ or ‘Depression Symptom’s’ was recorded in the medical file. This was established after reviewing the entire medical file.
Of the 221 clients entering an OYH clinical program between 1 April and 30 September 2007, 146 met the inclusion criteria. Of these, 121 (83%) had a diagnosis of depression during the audit period. Their mean age was 18.8 years (SD 2.9); 33.1% were male; none identified as indigenous, although four had ‘unknown’ ethnicity. The eligible clients had been with the assessment team (YAT) or inpatient unit on average 32.0 (SD 21.1) days (range 4 to 141) before allocation to a clinical program. The diagnosis or indication of a diagnosis of depression was recorded in 15 different ways at baseline assessment, the most common notation being “MDE or major depressive episode” (62%) with DSM-IV severity specifiers seldom used (<25%). Only 10 of the 121 clients with a depressive diagnosis during the audit period had a diagnosis of depression alone. The remainder had at least one additional diagnosis with these diagnoses classified into 20 categories.
The local ethics review committee approved the study (Melbourne Health Research and Ethics Committee; reference number 2008.18).
A data collection form or ‘audit’ form was designed specifically for the study, which included extensive instructions on coding for each item, and additional information describing codes for medication and diagnosis. Approximately 20% of the files were audited by visiting psychiatric registrars (n = 4), who were given extensive training in use of the audit form by the Principal author (SH) who audited the majority of files. A project specific database was designed and a research assistant entered all of the data from the audit forms.
Descriptive statistics including means, standard deviations and frequency counts were used to describe the timing and type of interventions used, the medications prescribed and the frequency of monitoring of symptoms and adverse outcomes. Where relevant, data analysis was undertaken according to age i.e. those aged 18 years and under and those aged over 18, given the NICE guidelines  apply to those 18 years and under. Minitab (version 16) and Microsoft Excel were used to manipulate data files and to obtain the descriptive statistics.
Establishing the severity of depression
Only 61 out of 121 (50.4%) patients with a diagnosis of depression had a baseline assessment of the severity of depression recorded using the service’s mandated tools (Health of Nations Outcome Scales; a UK scale measuring the health and social functioning of people with severe mental illness ): HoNOS (item 7 on this scale rates “problems with depressed mood” for >18 years) or HoNOSCA (item 9 on this scale rates “problems with emotional or related symptoms” for <18 years). When measurement of depression severity via other means, largely interview based clinical assessment, was taken into account, a total of 104 (86%) clients had severity recorded.
Timing of prescription of an antidepressant
Thirty-two (26.4%) young people diagnosed with depression during the audit period were already on an antidepressant at the time of entry to OYH. Of those who were antidepressant naïve on entry, 26 (29.2%) did not receive any medication during the audit period; 55 (61.8%) were prescribed one or more antidepressants during the audit period with 20 receiving an antidepressant alone.
Our earlier work  highlighted clinicians’ concerns that severe depression warranted earlier initiation of medication; therefore, we investigated the severity of depression in those who received a prescription for an antidepressant in less than six weeks of entry to OYH (N = 41). Only 33 had a baseline assessment of depression severity recorded (including HoNOS, HoNOSCA or interview based clinical assessment). Of these, 6% had ‘no problem’, 3% had mild depression, 51.5% had moderate depression and 39.4% had severe depression.
Type of medications prescribed
Type of first antidepressants for antidepressant naïve patients with a depression diagnosis; overall and by age group
All N = 15
18 years or younger N = 25
Over 18 Years N = 18
Number prescribed this medication
Number prescribed this medication
Number prescribed this medication
Monitoring of emergent suicidality and general progress
Number of patients with one or more successful contacts each week in the four-week follow up after prescription of anti-depressants
Any of the above
Twenty-five (30%) of 83 patients with a diagnosis of depression and receiving anti-depressants at some point during the audit period had a suicide ideation/risk assessment at least once a week for four weeks after the first prescription of anti-depressant.
Any current suicidal ideation/thoughts/intent?
Any suicide attempt since last contact or current?
Of the 25 patients with four weekly assessments, 10 had a clear answer to the question “Any current suicidal ideation/thoughts/intent?” in every one of the four weeks; for 15 it was unclear from the medical file and therefore recorded as such in the audit form. Only one of the 25 had a clear answer to the question “Any suicide attempt since last contact or current?” in every one of the four weeks.
Twenty-nine (35%) of the 83 were assessed for depression severity at least once per week in the four-week period. Only one of these patients was assessed with a recognized scale.
As anticipated, based on prior analysis of barriers to implementing youth depression guidelines , while practice is broadly in line with guideline recommendations, significant improvements are required in some areas to ensure recommendations are followed appropriately.
First, the current study shows less than 100% concordance with the assessment and recording of depression severity, despite treatment recommendations being largely determined by severity. Depression severity is often simply gauged by clinical judgement using DSM/ICD; however, this was seldom done and even in the context of a mandated tool (though not a specific depression scale), the lack of uniformity in establishing severity striking. In no case was there evidence that a depression scale measure was used.
Second, the majority of young people who were antidepressant naïve on entry to the service did not appear to have an adequate trial of psychological therapy before prescription of an antidepressant. Ours  and other research  has highlighted clinicians’ concerns about the applicability of evidence for those with severe presentations. The US primary care guidelines (Recommendation 3, pg 1319) , practice parameters of the AACAP (Recommendation 9, pg 1511)  and new Australian guidelines include a caveat allowing earlier prescription of medication in this case (Recommendation 5: pg 55) . However, the early prescription demonstrated in the current study was not entirely accounted for by the severity of depression.
It could be that medication was prescribed earlier for young people who declined to engage in psychological therapy. Our previous work has highlighted difficulties engaging young people with severe and complex presentations in psychotherapy. Again the US primary care guidelines (Recommendation 3, pg 1319)  and practice parameters of the AACAP (Recommendation 9, pg 1511) , the Australian guidelines (Recommendation 5, pg 55)  as well as the NICE guidelines (Recommendation 184.108.40.206, pg 127)  allow provision for medication in this case. This is somewhat paradoxical given the need for close monitoring in the case of medication prescription and the significant gaps between recommendations about monitoring and actual practice highlighted in this research.
Third, fluoxetine was the first medication prescribed for 92% for those 18 years and under, and 53.3% for those over 18 years. This is an encouraging result for those under 18 and suggests that unambiguously stated and potentially less complex recommendations are more likely to be carried out. The result for those over 18 was not unexpected given the audit was undertaken before the Australian guidelines , which include ‘good practice points’ recommending extrapolation of evidence for those up to the age of 25, were released. These good practice points are based on the FDA data showing an increased risk of suicide related behaviours after prescription of an antidepressant for those up to the age of 25 .
Finally, the Nice guidelines recommend “careful monitoring of adverse drug reactions, as well as for reviewing mental state and general progress; for example, weekly contact with the child or young person and their parent(s) or carer(s) for the first 4 weeks of treatment” (Recommendation 220.127.116.11 pg 127) for those initiated on an antidepressant. Our results show monitoring was undertaken far less frequently than recommended and was not done in a systematic nor precise way. This is consistent with previous US research . Our previous work regarding clinicians’ perceived lack of expertise and time to undertake systematic monitoring, particularly of medication induced adverse side effects . Together with research that has highlighted that a reliance on spontaneous report of side effects does not sufficiently identify all those at risk of suicide , the current results provide further impetus for services to invest in systems that allow regular collection of standardized information about adverse effects, emergent suicidality and resolution of depression symptoms, for example, an easily accessible online tool that incorporates all elements requiring monitoring.
Strengths and weaknesses of the study
We did not formally assess inter-rater reliability; rather we relied on a high level of detailed instruction in the audit form and intensive training. The Principal author also undertook the majority of the audit.
Our results are based on medical files records rather than observation of what actually took place. This limited the set of behaviours that we could investigate; for example, it was not practical to assess the type of psychotherapy e.g. CBT or IPT being conducted as the assessment of this from case notes was felt to be highly inaccurate.
This is the first study to our knowledge assessing this range of key clinician behaviours in a public youth mental health service relative to guideline recommendations for the treatment of depression in young people. Some research has been undertaken to assess the gaps between guideline recommendations and clinical practice [19, 21, 22], but each focus on only one or two recommendations. Our results are consistent with research on guideline implementation and the quality of depression care in adults. Adherence to guideline recommendations for adult depression is generally low in primary care e.g. [23–25] even when interventions aiming to improve evidence based care are implemented e.g. [26–28]. Of the few studies that have been undertaken in adult mental health specialist settings, adherence is better. For example in a national survey in the US, while appropriate care (defined as the respondent receiving medication or counseling consistent with guidelines) was only received by 19% of those who visited primary care providers, 90% of those visiting mental health specialists received appropriate care . One study looking at more specific indicators of guideline adherence by psychiatrists in private practice showed targeted training about providing guideline concordant care resulted in patients receiving more medication . Another study in psychiatric outpatient services showed adherence with all of a range of indicators of guideline adherence was seen in up to 55% of cases. Of note was the very low adherence to recommendations regarding routine outcome monitoring in the therapeutic phase .
The publication and dissemination of guidelines is not sufficient to ensure that evidence based recommendations are incorporated into every day clinical practice. This research has highlighted some areas that require specific improvement, including the systematic assessment and recording of depressive disorder symptom severity to ensure appropriate treatment planning. These findings are consistent with other research that has been undertaken and is likely to be applicable to youth public mental health services more broadly. Practice system tools are useful for ensuring the uptake of evidence into practice . For young people with depression, tools that allow for the ongoing monitoring of depression symptoms, adverse side effects - in particular treatment emergent suicide related behaviours - are critical given the increased risk of these outcomes for those on antidepressant medication [10, 32]. For young people who decline to engage in psychological therapy but nevertheless require medication, ongoing monitoring is critical. There is room for improvement with regard to ensuring an adequate trial of psychological therapy before medication is initiated, highlighting the need to establish the most effective elements of guideline recommended psychotherapy for young people and develop innovative ways to deliver these in ways that are engaging and acceptable to young people.
Finally, identifying and understanding the evidence-practice gaps, as well as barriers to implementing evidence allows the development of targeted strategies to ensure the uptake of evidence based guideline recommendations into everyday practice.
Orygen Youth Health receives funds from the Colonial Foundation. Sarah Hetrick is funded via a NHMRC training fellowship. The authors would like to thank Michaela Willet who assisted with the development of the audit tool and those who helped with audit including Daniel Betancor Pérez, Maria Carral Martinez, Carla Sofia Sanches Silva and Joana Pereira da Maia. The authors would also like to thank Kristina Iacovangelo for entering the data into the project specific database.
- Cheung AH, Zuckerbrot RA, Jensen PS, Ghalib K, Laraque D, Stein REK, the GLAD-PC Steering Group: Guidelines for adolescent depression in primary care (GLAD-PC): II treatment and ongoing management. Pediatrics. 2007, 120: e1313-1326. 10.1542/peds.2006-1395.View ArticlePubMedGoogle Scholar
- American Academy of Child and Adolescent Psychiatry (AACAP): Practice parameters for the assessment and treatment of children and adolescents with depressive disorders. J Am Acad Child Adoles Psychiatry. 2007, 46 (11): 1503-1526.View ArticleGoogle Scholar
- National Institute for Health and Clinical Excellence NICE: Depression in Children and Young People: Identification and management in primary, community and secondary care. 2005, The British Psychological Society, Leicester, UKGoogle Scholar
- McDermott B, Baigent M, Chanen A, Fraser L, Graetz B, Hayman N, Newman L, Parikh N, Peirce B, Proimos J, et al: beyondblue Expert Working Committee (2010) Clinical practice guidelines: Depression in adolescents and young adults. 2011, beyondblue: the national depression initiative, MelbourneGoogle Scholar
- Grol R: Successes and Failures in the Implementation of Evidence-Based Guidelines for Clinical Practice. Med Care. 2001, 39 (8(suppl2)): II-46-II-54.Google Scholar
- Grol R: Personal paper: beliefs and evidence in changing clinical practice. Br Med J. 1997, 315 (7105): 418-421. 10.1136/bmj.315.7105.418.View ArticleGoogle Scholar
- Bodenheimer T: The American health care system: the movement for improved quality in health care. New Engl J Med. 1999, 340 (6): 488-492. 10.1056/NEJM199902113400621.View ArticlePubMedGoogle Scholar
- Laughren TP: Clinical review: relationship between antidepressant drugs and suicidality in adults. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research. 2006, FDA, Silvers Spring, MD, http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4272b1-01-fda.pdf.Google Scholar
- Dubicka B, Hadley S, Roberts C: Suicidal behaviour in youths with depression treated with new-generation antidepressants: meta-analysis. Br J Psychiatry. 2006, 189: 393-398. 10.1192/bjp.bp.105.011833.View ArticlePubMedGoogle Scholar
- Hammad TA, Laugren T, Racoosin J: Suicidality in pediatric patients treated with antidepressant drugs. Arch Gen Psychiatry. 2006, 63: 332-339. 10.1001/archpsyc.63.3.332.View ArticlePubMedGoogle Scholar
- Hetrick SE, McKenzie JE, Merry SN: The use of SSRIs in children and adolescents. Curr Opin Psychiatry. 2010, 23: 53-57. 10.1097/YCO.0b013e328334bc92.View ArticlePubMedGoogle Scholar
- Goodyer IM, Wilkinson P, Dubicka B, Kelvin R: Forum: The use of selective serotonin reuptake inhibitors in depressed children and adolescents: commentary on the meta-analysis of Hetrick et al. Curr Opin Psychiatry. 2010, 23: 58-61. 10.1097/YCO.0b013e328334bce0.View ArticlePubMedGoogle Scholar
- Hebebrand J, March J, Herpertz-Dahlmann B: Commentary on ;Forum: use of antidepressants in children and adolescents. Curr Opin Psychiatry. 2010, 23: 62-67. 10.1097/YCO.0b013e328334bd2c.View ArticlePubMedGoogle Scholar
- Dudley M, Hadzi-Pavlovic D, Andrews D, Perich T: New-generation antidepressants, suicide and depressed adolescents: how should clinicians respond to changing evidence. Aust NZ J Psychiatry. 2008, 42: 456-466. 10.1080/00048670802050538.View ArticleGoogle Scholar
- Hetrick SE, Simmons M, Thompson A, Parker AG: What are specialist mental health clinician attitudes to guideline recommendations for the treatment of depression in young people?. Aust NZ J Psychiatry. 2011, 45 (11): 993-1001. 10.3109/00048674.2011.619161.View ArticleGoogle Scholar
- Nelson TD, Steele RG, Mize JA: Practitioner attitudes toward evidence-based practice: themes and challenges. Adm Policy Ment Health & Ment Health Serv Res. 2006, 33: 398-409. 10.1007/s10488-006-0044-4.View ArticleGoogle Scholar
- Wing JK, Curtis RH, Beevor AS: HoNOS: Health of the Nation Outcome Scales: Report on Research and Development July 1993-December 1995. 1996, Royal College of Psychiatrists, LondonGoogle Scholar
- Stone M, Laughren T, Jones ML, Levenson M, Holland PC, Hughes A, Hammad TA, Temple R, Rochester G: Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration. Br Med J. 2009, 339: b2880-10.1136/bmj.b2880.View ArticleGoogle Scholar
- Morrato EH, Libby AM, Orton HD, de Gruy FV, Brent DA, Allen R, Valuck RJ: Frequency of provider contact after FDA advisory on risk of pediatric suicidality with SSRIs. Am J Psychiatry. 2008, 165: 42-50.View ArticlePubMedGoogle Scholar
- Brent DA, Emslie GJ, Clarke GN, Asarnow J, Spirito A, Ritz L, Vitiello B, Iyengar S, Birmaher B, Ryan ND, et al: Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) study. Am J Psychiatry. 2009, 166 (4): 418-426. 10.1176/appi.ajp.2008.08070976.View ArticlePubMedPubMed CentralGoogle Scholar
- Page AN, Swannell S, Martin G, Hollingworth S, Hickie IB, Hall WD: Sociodemograhpic correlates of antidepressant utilisation in Australia. Med J Aust. 2009, 190: 479-483.PubMedGoogle Scholar
- Perera A, Gupta P, Samuel R, Berg B: A survey of anti-depressant prescribing practice and the provision of psychological therapies in a South London CAMHS from 2003–2006. Child Adolesc Ment Health. 2007, 12 (2): 70-72. 10.1111/j.1475-3588.2007.00445.x.View ArticleGoogle Scholar
- Smith L, Gilhooly K, Walker A: Factors Influencing Prescribing Decisions in the Treatment of Depression: A Social Judgement Theory Approach. Appl Cognitie Psych. 2003, 17: 51-63. 10.1002/acp.844.View ArticleGoogle Scholar
- Young AS, Klap R, Sherbourne CD, Wells KB: The quality of care for depressive and anxiety disorders in the United States. Arch Gen Psychiatry. 2001, 58: 55-61. 10.1001/archpsyc.58.1.55.View ArticlePubMedGoogle Scholar
- Hepner KA, Rowe M, Rost K, Hickey SC, Sherbourne CD, Ford DE, Meredith LS, Rubenstein LV: The effect of adherence to practice guidelines on depression outcomes. Ann Intern Med. 2007, 147 (5): 320-329.View ArticlePubMedGoogle Scholar
- Linden M, Schotte K: A randomized controlled clinical trial on dosage selection and treatment outcome with doxepin comparing “guideline exposed” and “guideline naive” physicians. Pharmacopsychiatry. 2007, 40: 77-81. 10.1055/s-2007-972574.View ArticlePubMedGoogle Scholar
- Lin EHB, Simon GE, Katzelnick DJ, Pearson SD: Does physician education on depression management improve treatment in primary care?. Gen Intern Med. 2001, 16: 614-619. 10.1046/j.1525-1497.2001.016009614.x.View ArticleGoogle Scholar
- Worrall G, Angel J, Chaulk P, Robbins M: Effectiveness of an educational strategy to improve family physicians detection and management of depression:a randomized controlled trial. Can Med Assoc J. 1999, 161 (Pt1): 37-40.Google Scholar
- Linden M, Westram A, Schmidt LG, Haag C: Impact of the WHO depression guideline on patient care by psychiatrists: a randomized controlled trial. Euro Psychiatry. 2008, 23 (6): 403-408. 10.1016/j.eurpsy.2008.04.001.View ArticleGoogle Scholar
- Van Fenema E, Van Der Wee NJA, Bauer M, Witte CJ, Zitman FG: Assessing adherence to guidelines for common mental disorders in routine clinical practice. Int J Qual Health Care. 2012, 24 (1): 72-79. 10.1093/intqhc/mzr076.View ArticlePubMedGoogle Scholar
- Margolis KL, Solberg LI, Asche SE, Whitebird RR: Use of practice system tools by medical groups for depression. Am J Manag Care. 2007, 13 (1): 305-311.PubMedGoogle Scholar
- Hetrick SE, Merry S, McKenzie J, Sindahl P, Proctor M: Selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in children and adolescents (Review). Cochrane Database of Systematic Reviews: The Cochrane Library. 2007, Issue 3(Art. No.: CD004851. DOI: 10.1002/14651858)Google Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6963/12/178/prepub
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