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Table 2 Occurrence and preventability of ADEs among surgical, nonsurgical and all inpatients

From: Occurrence and preventability of adverse drug events in surgical patients: a systematic review of literature

Population Data Unit Classen 1991[17] Bates 1993[14] Bates 1995[15] Lazarus 2003[18] Berga Cullere 2008[16] Morimoto 2011[19]
Surgical Records Admissions 23,458* 151‡ 493‡ - - 1,469
Patients - - - - 775 -
Patient-days - 1,066 4,339 - - -
No. ADEs ADEs 480 5 39* - - 407
Patients with ADE - - - - 69 -
Occurrence ADEs (95% CI) /100 admissions 2.0 (1.9-2.2)* 3.3 (0.5-6.2)‡ 7.9 (5.5-10.3)‡ - - 27.7 (25.4-30.0)
/100 patients - - - - 8.9 (6.9-10.9)* -
/1,000 patient-days - 4.7 (1.5-10.9)* 8.9 (6.1-11.7) - - -
Preventability ADEs   - - 7/39 (18% (5.9-30.0))* - 37/69 (54% (41.9-65.4) of the ADE patients) -
Nonsurgical Records Admissions 8,064* 142‡ 527‡ - - 1,531
Patients - - - - 775 -
Patient-days - 1,003 11,499 - - -
No. ADEs ADEs 251 13 122* - - 504
Patients with ADE - - - - 90 -
Occurrence ADEs (95% CI) /100 admissions 3.1 (2.7-3.5)* 9.2 (4.4-13.9)‡ 23.1 (19.5-26.8)‡ - - 32.9 (30.6-35.3)
/100 patients - - - - 11.6 (9.4-13.9)* -
/1,000 patient-days - 13.0 (6.9-22.2)* 10.6 (8.7-12.4) - - -
Preventability ADEs   - - 34/122 (28% (19.9-35.8))* - 45/90 (50% (39.7-60.3) of the ADE patients) -
Overall Records Admissions 36,653 420 4,031 4,320 † - 3,459
Patients - - - - 1,550 -
Patient-days - 2,967 21,412 - - -
No. ADEs ADEs 731 27 247 98† 194 1,010
Patients with ADE - - - - - -
Occurrence ADEs (95% CI) /100 admissions 2.0 (1.9-2.1)* 6.4 (4.1-8.8)* 6.1 (5.4-6.9) 2.3 (1.8-2.7)† - 29.2 (27.7-30.7)
/100 patients - - - - 12.5 (10.9-14.2)* -
/1,000 patient-days - - - - - -
Preventability ADEs   - 15/27 (56%) 70/247 (28%) - 91/194 (47%) 141/1010 (14%)
  1. *Calculated from rough data; ‡estimated based on rough data i.e. the numbers of admissions were calculated by dividing the patient-days by the length of hospital stay; 95% CI indicates the 95% confidence interval; †this study solely included surgical patients.