You are viewing the site in preview mode

Skip to main content

Advertisement

Table 3 Nature of ADEs in all inpatients

From: Occurrence and preventability of adverse drug events in surgical patients: a systematic review of literature

Data Classen 1991[17] Bates 1993[14] Bates 1995[15] Lazarus 2003[18] Berga Cullere 2008[16] Morimoto 2011[19]
Severity ADEs 101 (14%) Severe - 3 (1%) Death - - 16 (2%) Death
600 (82%) Moderate   30 (12%) Life-threatening 49 (5%) Life-threatening
30 (4%) Mild   73 (30%) Serious    330 (33%) Serious
141 (57%) Significant 615 (61%) Significant
Severity Preventable ADEs - - 0 Death - 4 (4%) Life-threatening, 10 (11%) Severe -
14 (20%) Life threatening 77 (85%) Moderate  
30 (43%) Serious
26 (37%) Significant
Causality ADEs 450 (62%) Definite 56% Probable - - 2 (1%) Definite -
276 (38%) Probable 44% Possible † 98 (51%) Likely  
5 (1%) Possible     55 (29%) Possible  
39 (20%) Unclassified  
Medication accountable for ADEs 227 (31%) Analgesics 25% Antibiotics 73 (30%) Analgesics 86 (88%) Analgesics 32 (16%) Antibiotics 365 (36%) Antibiotics
171 (23%) Antibiotics 15% Cardiac 59 (24%) Antibiotics 5 (5%) Anti-coagulants 18 (9%) Opiates 87 (9%) Sedatives
142 (19%) Cardiovascular 12% Anticoagulants 20 (8%) Sedatives 3 (3%) Antianxiety 11 (6%) Corticoids 78 (8%) NSAIDs
68 (9%) Anti-coagulants 48% Other † 18 (7%) Antineoplastics 2 (2%) Diuretics 10 (5%) Analgesics 73 (7%) Laxatives
18 (2%) Psychotherapeutic ¥   9 (4%) Cardiovascular ¥ 2 (2%) Antibiotics 8 (4%) Diuretics ¥ 52 (5%) Antihypertensives ¥
Medication accountable for Preventable ADEs - - 20 (29%) Analgesics - - 26 (18%) Electrolytes
6 (9%) Antibiotics 25 (18%) NSAIDs
7 (10%) Sedatives 19 (13%) Antibiotics
5 (7%) Antipsychotic 9 (6%) Antihypertensives
4 (6%) Diabetes ¥ 6 (4%) Other analgesics ¥
Stage of medication errors associated with Preventable ADEs - - 39 (56%) Ordering - - 45 (35%) Ordering
4 (6%) Transcription 0 Transcription
3 (4%) Dispensing 0 Dispensing
24 (34%) Administration 15 (11%) Administration
77 (55%) Monitoring
  1. † The study provided percentages, no rough data were available; ¥ The list of medication accountable for ADEs consisted of more than 5 items in these studies, only the top 5 of that list is displayed here.