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Table 3 Adjusted odds ratios for chemotherapy- induced neutropenic complications requiring inpatient care in subgroup and secondary analyses

From: Risk and consequences of chemotherapy-induced neutropenic complications in patients receiving daily filgrastim: the importance of duration of prophylaxis

  Unadjusted Adjusted*
  No. of cycles No. of events % Odds ratio Odds ratio
Narrow definition of CINC
Days of Filgrastim Prophylaxis
1-3 8,371 130 1.6% 1.15 (0.77,1.72) 1.60 (1.05,2.45)
4-6 3,691 67 1.8% 1.35 (0.88,2.09) 1.74 (1.11,2.72)
> = 7 2,226 30 1.3%
Broad definition of CINC
First cycle only
  Days of Filgrastim Prophylaxis
1-3 1,054 74 7.0% 1.37 (0.81, 2.30) 1.56 (0.89, 2.74)
4-6 482 24 5.0% 0.95 (0.51, 1.76) 1.11 (0.58, 2.12)
> = 7 363 19 5.2%
Breast cancer
  Days of Filgrastim Prophylaxis
1-3 4,038 94 2.3% 1.44 (0.86, 2.39) 1.75 (1.02, 3.00)
4-6 1,829 49 2.7% 1.66 (0.96, 2.86) 1.92 (1.09, 3.38)
> = 7 1,103 18 1.6%
Lung cancer
  Days of Filgrastim Prophylaxis
1-3 630 44 7.0% 13.52 (1.85, 98.79) 20.20 (1.92, 212.36)
4-6 349 15 4.3% 8.08 (1.06, 61.70) 14.54 (1.33, 158.65)
> = 7 181 1 0.6%
Colorectal cancer
  Days of Filgrastim Prophylaxis
1-3 1,327 21 1.6% 1.64 (0.22, 12.32) 1.88 (0.21, 16.67)
4-6 360 9 2.5% 2.62 (0.33, 20.89) 2.54 (0.27, 23.54)
>=7 103 1 1.0%
NHL
  Days of Filgrastim Prophylaxis
1-3 830 63 7.6% 1.86 (1.13, 3.05) 2.06 (1.19, 3.55)
4-6 474 28 5.9% 1.42 (0.80, 2.52) 1.76 (0.95, 3.23)
> = 7 519 22 4.2%
  1. *Results adjusted for patient, cancer, and treatment characteristic listed in Table 2.