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Table 3 Patient pre-index clinical characteristics

From: Characteristics affecting oral anticoagulant therapy choice among patients with non-valvular atrial fibrillation: a retrospective claims analysis

Characteristics All patient cohorts OAC-naïve cohorts
Dabigatran (n = 3,019) Warfarin (n = 17,301) P-value Dabigatran (n = 815) Warfarin (n = 1,590) P-value
N/mean %/SD N/mean %/SD N/mean %/SD N/mean %/SD
Summary comorbidity/severity scores           
CHADS2, mean, SD 1.9 ±1.3 2.2 ±1.3 <.0001 1.7 ±1.4 2.2 ±1.4 <.0001
ATRIA, mean, SD 2.3 ±2.1 3.0 ±2.3 <.0001 2.0 ±2.0 3.1 ±2.6 <.0001
Elixhauser (ECI), mean, SD 4.0 ±2.2 4.3 ±2.3 <.0001 3.7 ±2.1 4.5 ±2.6 <.0001
Selected pre-index comorbidities, n,%           
Any ischemic stroke 497 16.5 2,567 14.8 0.0213 127 15.6 259 16.3 0.6550
Any TIAs 169 5.6 789 4.6 0.0131 46 5.6 90 5.7 0.9870
Heart failure 603 20.0 4,592 26.5 <.0001 136 16.7 445 28.0 <.0001
Hypertension 2,394 79.3 14,202 82.1 0.0003 626 76.8 1,288 81.0 0.0157
Diabetes mellitus 895 29.6 5,683 32.8 0.0005 207 25.4 508 31.9 0.0009
Chronic kidney disease (stages II-V) 172 5.7 1,265 7.3 0.0014 45 5.5 154 9.7 0.0005
Heart rate and heart rhythm control procedures* 155 5.1 436 2.5 <.0001 44 5.4 66 4.1 0.1656
Pre-index use of selected medications           
Use of warfarin, n,% 2,204 73.0 15,711 90.8 <.0001 0 0.0 0 0.0 NA
≥1 PT tests, n,% 2,111 69.9 13,575 78.5 <.0001 NA NA NA NA NA
Parenteral anticoagulants, n,% 231 7.7 974 5.6 <.0001 13 1.6 59 3.7 0.0040
Any platelet inhibitor 648 21.5 2,768 16.0 <.0001 225 27.6 341 21.4 0.0007
Prescription NSAIDs 456 15.1 1,791 10.4 <.0001 145 17.8 190 11.9 <.0001
Any rate control medication 2,475 82.0 13,916 80.4 0.0472 614 75.3 1,119 70.04 0.0103
Any rhythm control medication, n,% 948 31.4 3,238 18.7 <.0001 286 35.1 353 22.2 <.0001
Any rate or rhythm control medications 2,562 84.86 14,223 82.21 0.0004 654 80.3 1,164 73.2 0.0001
Any dyspepsia medication, n,% 749 24.8 4,122 23.8 0.2424 173 21.3 362 22.8 0.3900
Proton-pump inhibitor (PPI) 689 22.8 3,701 21.4 0.0781 159 19.5 320 20.1 0.7201
Histamine type-2 receptor antagonist (H2RA) 100 3.3 583 3.4 0.8717 26 3.2 55 3.5 0.7293
  1. *Includes insertion of pacemaker or defibrillator, cardioversion – electrical, left atrial catheter ablation and surgical ablation.