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Table 4 Logistic regression of dabigatran use (versus warfarin) among all patients (n = 20,320) and OAC-naïve patients (n = 2,405)

From: Characteristics affecting oral anticoagulant therapy choice among patients with non-valvular atrial fibrillation: a retrospective claims analysis

Independent variables All-patient cohort† OAC-naïve cohort#
Odds ratio 95% confidence limits P-value Odds ratio 95% confidence limits P-value
Intercept -1.34    <.0001 -1.26    <.0001
Female (reference = male) 0.87 0.79 0.96 0.0035 1.02 0.83 1.26 0.8362
55-64 age group (reference = 18–54) 1.00 0.86 1.16 0.9517 0.90 0.68 1.21 0.4865
65-74 age group 0.64 0.55 0.75 <.0001 0.59 0.43 0.81 0.0010
75-84 age group 0.44 0.37 0.53 <.0001 0.40 0.28 0.58 <.0001
85+ age group 0.39 0.31 0.48 <.0001 0.42 0.26 0.66 0.0002
Midwest region indicator (reference = west) 0.55 0.49 0.62 <.0001 0.43 0.34 0.56 <.0001
Northeast region indicator 0.90 0.80 1.01 0.0816 0.93 0.70 1.23 0.6125
South region indicator 1.05 0.93 1.19 0.4389 1.12 0.85 1.49 0.4282
PPO insurance indicator (reference = HMO) 1.68 1.48 1.92 <.0001 1.47 1.10 1.96 0.0089
Other insurance type indicator 1.31 1.13 1.52 0.0003 1.20 0.87 1.66 0.2770
Total ATRIA score 0.98 0.95 1.00 0.0477 0.91 0.86 0.96 0.0005
Pre-index heart failure 0.78 0.70 0.87 <.0001 0.76 0.59 0.97 0.0253
Pre-index hypertension 1.16 1.04 1.30 0.0083 1.32 1.04 1.69 0.0246
Pre-index warfarin 0.34 0.31 0.38 <.0001     
Pre-index any anti-platelet/NSAIDS fill 1.15 1.03 1.28 0.0097     
Prior use of any dyspepsia medication 1.13 1.03 1.25 0.0146     
Cardiology specialty of index OAC prescriber indicator (reference = PCP/family/internal medicine) 3.12 2.77 3.51 <.0001 3.59 2.68 4.81 <.0001
Other specialty of index OAC prescriber 1.94 1.72 2.20 <.0001 2.22 1.65 2.97 <.0001
Pre-index PT test use 0.70 0.64 0.78 <.0001     
Pre-index any heart rate/rhythm control medication fill 1.19 1.06 1.34 0.0037     
Pre-index any Afib related procedure 1.53 1.38 1.71 <.0001     
Pre-index ischemic stroke 1.34 1.18 1.53 <.0001 1.42 1.06 1.90 0.0183
Pre-index TIA 1.24 1.02 1.51 0.0281     
Total patient out of pocket pharmacy costs (per $1 K) during the pre-index period 1.04 1.01 1.08 0.0251 1.32 1.17 1.48 <.0001
  1. †C-statistic = 0.7530; Hosmer and Lemeshow Test (p-value = 0.6416).
  2. #C-statistic = 0.7360; Hosmer and Lemeshow Test (p-value = 0.0754).