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Table 4 Results, summary of the judgements made by the 17 evaluators of the quality for each of the outcomes presented in the 12 examples in the pilot study.

From: Systems for grading the quality of evidence and the strength of recommendations II: Pilot study of a new system

Outcome High Moderate Low Very low Consensus Comments
Depression severity 6/17 10/17 - - Moderate  
Transient side effects 7/17 10/17 - - High Changed to little uncertainty
Poisoning fatalities - 4/17 7/17 6/17 Moderate Upgraded for very strong association
Stroke 15/17 2/17 - - High  
Extracranial hemorrage 16/16 - - - High  
All cause mortality 12/17 5/17 - - - Agreed to remove this outcome
Pain at rest 16/17 1/17 - - High  
Pain ay motion 15/17 2/17 - - Moderate Uncertainty about directness of outcome measure
Mobility 3/17 14/17 - - Moderate  
Quality of life 1/17 11/17 5/17 - Moderate  
Dropout due to side effects 14/17 3/17 - - High  
Serious gi complications - 3/17 8/17 6/17 - Need more information before consensus
All cause mortality 2/17 15/17 - - Moderate  
Non-fatal stroke 17/17 - - - High  
Non-fatal MI 17/17 - - - High  
Death 13/17 4/17 - - High  
Non-fatal MI 11/16 5/16 - - High  
All cause death 12/17 5/17 - - Moderate If reporting bias, otherwise high
Major bleeding 15/17 2/17 - - High  
Recurrent thromboembolism 6/17 11/17 - - High  
Clinical cure - 13/17 4/17 - Moderate  
Dropout due to side effects - 10/17 7/17 - Moderate  
Relapse 2/17 11/17 4/17 - Moderate  
Tuberculosis 2/17 10/17 5/17 - Moderate  
TB death 8/17 8/17 1/17 - High  
TB meningitis 1/17 4/17 12/17 - Moderate Strong association
Serious adverse events 1/12 - - 11/12 - No data, outcome removed
Condition unchanged 5/17 19/17 2/17 - - No consensus regarding sparse data
Poor outcome- surgeon rated 9/17 8/17 - - - Need bias information before consensus
2nd procedure needed 9/17 8/17 - - Moderate  
No success – objective rater 5/17 10/17 2/17 - - No consensus regarding sparse data
Risks & side effects 1/15 2/15 2/15 10/15 - No data, outcome removed
Dental caries – start - - 8/17 9/17 Very low  
Dental caries – stop - - 5/17 12/17 Very low  
Dental florosis - 1/17 3/17 13/17 Very low  
Bone fracture - 1/17 3/17 13/17 Very low  
Cancer mortality - 1/17 2/17 14/17 Very low  
All injuries - 1/17 12/17 4/17 Very low Question changed
Correct use early 8/17 5/17 4/17 - High Question changed
Correct use follow up 2/17 8/17 6/17 1/17 High Question changed
Possession of seat 7/17 6/17 3/17 - High Question changed
CHD 11/13 2/13 - - High  
Breast cancer 11/13 2/13 - - High  
Stroke 11/13 2/13 - - High  
Colorectal cancer 11/13 2/13 - - High  
Endometrial cancer 11/13 2/13 - - High  
Hip fracture 11/13 2/13 - - High