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Table 6 Selection of Studies for Re-assessment

From: The Systematic Guideline Review: Method, rationale, and test on chronic heart failure

Publication Type No. of Cited No. of Excluded Reason for Preclusion
Systematic Reviews/Meta-analyses (SR) 36 13 Results outdated by more recent SR
   3 SR reported surrogate outcomes where clinical outcomes were available
   2 SR did not contain target population
   4 SR was out of the scope of the target guideline
Randomized Controlled Trials (RCT) 170 132 RCT included in re-evaluated SR
   8 Results on surrogate outcomes where clinical outcomes were available
   12 Set aside for further comprehensive research
   12 RCT was out of the scope of the target guideline
Traditional Reviews, Editorials 33 33 Provided no systematic evidence
Miscellaneous Clinical Studies 70 69 Study design and/or sample size N<50 were not expected to provide strong evidence; further search for high-level evidence was seen to be more effective than re-appraisal
Total 309 288