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Table 3 Cost-effectiveness estimations for different interventions in patients with coronary artery disease

From: Advocacy for outpatient cardiac rehabilitation globally

Author (year) Intervention Patient population Estimated savings
Ades et al. (1997) [46] CR versus with other post-MI treatment interventions Post MI or revascularization CR was found to result in savings of 2,130 $/YLS in 1980, which was projected to be 4,950 $/YLS for 1995
Johanneson et al. (1997) [47] Statins (i.e., Simvastatin) versus no statins Angina or MI Simvastatin use resulted in $3,800 to $27,400 cost per year of life gained
Cleland et al. (1997) [48] CABG + Medical therapy + aspirin versus CABG + medical therapy + aspirin + statin versus medical+aspirin+statin versus medical + aspirin Chronic stable angina $36,709, $55,156 and $23,730 per QALY for each comparison over 5 years
Chan et al. (2007) [49] High intensity versus low intensity statin Acute coronary syndrome, Chronic coronary disease From $20,000 to $35,000 if cost difference of statins is between $2 and $3.50 From $70,000 to $125,000 if cost difference of statins is between $2 and $3.50
Dendale et al. (2008) [50] CR versus no CR Post PCI Reduction in total health care costs with CR (€4,862/patient versus €5,498 Euro/patient)
Weinbtraub et al. (2008) [51]a PCI and medical therapy versus Medical therapy alone Stable angina $168,000 to $300,000 per QALY gained with PCI
Wilson et al. (2012) [52] Smoking cessation with varenicline plus counseling versus counseling only CVD Savings ranging from €5151 - €6120 per QALY gained
Smith et al. (2013) [53] Implantable cardiac defibrillator versus no defibrillator Primary prevention of sudden death in patients with left ventricular ejection fraction <40% (ischemic and non-ischemic) €43,993 per QALY gained compared to no defibrillator
  1. Abbreviations: $/YLS dollars per year of life saved, CVD cardiovascular disease, MI myocardial infarction, PCI percutaneous coronary intervention, QALY, quality-adjusted life year
  2. aCOURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive druG Evaluations) trial