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Table 2 Selected parameters for estimating cost-effectiveness of HPV vaccination using the PRIME model

From: Cervical cancer treatment costs and cost-effectiveness analysis of human papillomavirus vaccination in Vietnam: a PRIME modeling study

No Parameter Average value/value Range Source
1 Vaccine delivery cost per FIG $ 10.4 $ 9.5-$ 11.3 Costing study
2 Cancer treatment cost    Costing study
  Scenario 5 (IA1 - IIB proximal treated by Radical hysterectomy) $ 368.3 N/A  
  Scenario 6 (IA1 - IIB proximal treated by Radical hysterectomy + Chemoradiation) $ 8700.1 N/A  
  Scenario 7 (IA1 - IIB proximal treated by Radical hysterectomy + Radio therapy (Intr)) $ 2209.6 N/A  
  Scenario 8 (IA1 - IIB proximal treated by Radical hysterectomy + Radio-therapy (External beam)) $ 1449.9 N/A  
  Scenario 9 (IIB distant – IVB treated by Chemoradiation) $ 11448.1 N/A  
  Scenario 10 (IIB distant – IVB treated by Radio therapy (Intra + External)) $ 5166.52 N/A  
  Scenario 11 (average cost of all scenarios) $ 4,890.44 N/A  
3 DALYs lost per non-fatal cancer episode 0.7   Literature review
4 DALYs lost per fatal cancer episode (excluding life years lost) 0.8   Literature review
5 Epidemiological data    Literature review
  Cervical cancer incidence in 2012 6.1 per 100000   GLOBOCAN 2012
20.5 per 100000
26.7 per 100000
31.3 per 100000
32.1 per 100000
26.2 per 100000
20.5 per 100000
13 per 100000
  Cervical cancer mortality in 2012 1.1 per 100000   GLOBOCAN 2012
6.5 per 100000
15.1 per 100000
18.8 per 100000
21.3 per 100000
21.8 per 100000
20 per 100000
16.1 per 100000
5.3 per 100000
  All-cause mortality in 2012 100 - 52 800 per 100 000 (depending on age)   National statistics