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Table 3 Knowledge of community pharmacists in Palestine on generic medicine (n = 302)

From: Knowledge, attitudes and practices of community pharmacists on generic medicines in Palestine: a cross-sectional study

Knowledge item Correct response N (%) Incorrect response N (%) I don’t know N (%)
1. The term generic medicine is a drug product marketed under the drugs non-proprietary approved name or a product marketed under a different brand name (proprietary) name. (T) 192 (63.6) 93 (30.8) 17 (5.6)
2. Generic products must be bioequivalent to the innovator brand before they can be approved to be marketed in many developed and some developing countries. (T) 280 (92.7) 9 (3.0) 13 (4.3)
3. Product quality data are NOT required before a generic product can be registered in such countries that require bioequivalent data. (F) 21 (7.0) 239 (79.1) 42 (13.9)
4. Provided that a generic product conforms to bioequivalence and product quality requirements, it is assumed that its efficacy, quality and safety are similar to the original branded product. (T) 286 (94.7) 13 (4.3) 3 (1.0)
5. Two pharmaceutical products are bioequivalent if they are pharmaceutically equivalent and their bioavailabilities are similar to such a degree that their effects, with respect to both efficacy and safety, can be expected to be essentially the same. (T) 251 (83.1) 23 (7.6) 28 (9.3)
6. For generic drug to be bioequivalent to its innovator brand or other generics, the 90% confidence intervals for the ratio of each pharmacokinetics parameters (i.e. Cmax and AUC), must lie within the range of 90–110%. (F) 156 (51.7) 38 (12.6) 108 (35.8)
7. A generic medicine is usually manufactured without a license from the innovator company, but marketed after expiry of patent or other exclusivity rights. (T) 179 (59.3) 87(28.8) 36 (11.9)
8. When two pharmaceutical products are bioequivalent, it means that the Cmax and AUC ratios estimated for each formulation can vary by −20 to +25%. (T) 68 (22.5) 94(31.1) 140 (46.4)
9. Where there is a generic substitution policy, the community pharmacists is allowed to dispense a different brand of the drug, but may or may not refer back to the prescriber depending on the jurisdiction/law. (F) 263 (87.1) 23 (7.6) 16 (5.3)
10. If a generic medicine is bioequivalent to a branded medicine, it means that it is also therapeutically equivalent. (T) 231 (76.5) 56(18.5) 15 (5.0)