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Table 2 Number of DDDs/1000 inhabitants/day of analgesics during the pre-withdrawal period (Jan-June 2009) and the post-withdrawal period (Jan-June 2012)

From: Use of analgesics in France, following dextropropoxyphene withdrawal

  Pre-withdrawal Post-withdrawal Percentage changes
WHO ladder step 1
 NSAIDs 29,41 26,53 −9,8%
 PC 30,79 39,16 + 27,2%
 ALL STEP 1 60,20 65,69 + 9,1%
WHO ladder step 2
 DXP / PC 28,82 0,00 −100%
 CODEINE 0,03 0,05 + 50,0%
 CODEINE / PC 3,04 5,06 + 66,3%
 OPIUM / PC 1,40 2,55 + 83,0%
 TRAMADOL 3,58 3,99 + 11,3%
 TRAMADOL / PC 9,68 13,39 + 38,3%
 ALL STEP 2 46,56 25,05 −46,2%
WHO ladder step 3
 MORPHINE-LIKE DRUGS 1,90 2,50 + 31,3%
 MORPHINE 0,79 0,84 + 5,5%
 ALL STEP 3 2,70 3,33 + 23,7%
 ALL ANALGESICS 109,45 94,07 −14,1%