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Table 2 Properties of evaluated algorithms

From: Validating an algorithm to identify metastatic gastric cancer in the absence of routinely collected TNM staging data

Algorithm Se (95% CI) Sp (95% CI) PPV (95% CI) NPV (95% CI) A (95% CI)
+/− 3 Months Diagnosis Date
Conservative Diagnosis Codes
1. 1+ hospitalization 50 (47.2–52.8) 92.5 (90.9–94.0) 88.8 (86.4–91.0) 60.9 (58.5–63.3) 69.4 (67.6–71.3)
2. 1+ hospitalization or 2+ outpatient 57.8 (55.1–60.5) 86.9 (84.8–88.8) 84 (81.4–86.3) 63.4 (60.9–65.9) 71 (69.2–72.9)
3. 1+ hospitalization or 1+ outpatient 61.2 (58.5–63.9) 84.2 (82.0–86.3) 82.1 (79.6–84.6) 64.6 (62.1–67.1) 71.7 (69.8–73.5)
Less Conservative Diagnosis Codes
4. 1+ hospitalization 52.9 (50.2–55.7) 87.9 (85.9–89.8) 83.8 (81.2–86.3) 61.1 (58.6–63.5) 68.9 (67.0–70.8)
5. 1+ hospitalization or 2+ outpatient 60.4 (57.7–63.2) 82.2 (79.9–84.4) 80.1 (77.6–82.6) 63.6 (61.0–66.1) 70.3 (68.5–72.1)
6. 1+ hospitalization or 1+ outpatient 64.2 (61.5–66.8) 79.7 (77.4–82.2) 79 (76.5–81.4) 65.2 (62.5–67.8) 71.3 (69.5–73.1)
Most Inclusive Diagnosis Codes
7. 1+ hospitalization 53.6 (50.9–56.4) 86.9 (84.8–88.9) 82.9 (80.3–85.5) 61.2 (58.7–63.7) 68.8 (66.9–70.7)
8. 1+ hospitalization or 2+ outpatient 69.5 (66.9–72.0) 68 (65.2–70.8) 72.1 (69.4–74.5) 65.2 (62.4–68.0) 68.8 (66.9–70.6)
9. 1+ hospitalization or 1+ outpatient 76.3 (73.9–78.6) 58.7 (55.8–61.7) 68.7 (66.2–71.1) 67.5 (64.4–70.5) 68.2 (66.3–70.1)
+/− 6 months Diagnosis Date
Conservative Diagnosis Codes
10. 1+ hospitalization 57.5 (54.7–60.3) 90.1 (88.3–91.8) 87.4 (85.0–89.5) 64.1 (61.7–66.6) 72.4 (70.6–74.2)
11. 1+ hospitalization or 2+ outpatient 65.8 (63.2–68.4) 82.3 (80.0–84.6) 81.6 (79.2–83.9) 66.9 (64.4–69.5) 73.3 (71.6–75.1)
12. 1+ hospitalization or 1+ outpatient 68.6 (66.1–71.2) 79.1 (76.7–81.6) 79.6 (77.2–82.0) 67.9 (65.3–70.5) 73.4 (71.6–75.1)
Less Conservative Diagnosis Codes
13. 1+ hospitalization 60.1 (57.4) 84.4 (82.2–86.5) 82.1 (79.6–84.5) 64 (61.5–66.5) 71.2 (69.4–73.0)
14. 1+ hospitalization or 2+ outpatient 68.1 (65.6–70.6) 77.1 (74.5–79.6) 77.9 (75.4–80.3) 67 (64.4–69.7) 72.2 (70.4–74.0)
15. 1+ hospitalization or 1+ outpatient 71 (68.6–73.5) 73.8 (71.2–76.4) 76.3 (73.9–78.7) 68.2 (65.5–70.9) 72.3 (70.5–74.0)
Most Inclusive Diagnosis Codes
16. 1+ hospitalization 61.1 (58.4–63.8) 83 (80.7–85.2) 81 (78.5–83.4) 64.2 (61.7–66.8) 71.1 (69.3–73.0)
17. 1+ hospitalization or 2+ outpatient 77.4 (75.1–79.7) 57.8 (54.8–60.6) 68.5 (66.0–70.9) 68.2 (65.3–71.3) 68.4 (66.6–70.2)
18. 1+ hospitalization or 1+ outpatient 82.7 (80.6–84.8) 48.2 (45.2–51.2 65.5 (63.1–67.8) 70.1 (66.7–73.5) 66.9 (65.0–68.9)
−3 months Diagnosis, No Time Limit
Conservative Diagnosis Codes
19. 1+ hospitalization 70.7 (68.1–73.2) 69.9 (67.1–72.6) 73.6 (71.0–76.0) 66.7 (63.9–69.5) 70.3 (68.4–72.1)
20. 1+ hospitalization or 2+ outpatient 77.4 (75.1–79.6) 60.4 (57.5–63.3) 69.9 (67.5–72.3) 69.2 (66.2–72.2) 69.6 (67.8–71.5)
21. 1+ hospitalization or 1+ outpatient 80.2 (78.0–82.4) 55.6 (52.7–58.6) 68.2 (65.8–70.6) 70.2 (67.1–73.3) 68.9 (67.1–70.9)
Less Conservative Diagnosis Codes
22. 1+ hospitalization 72.9 (70.5–75.3) 63.9 (61.1–66.8) 70.6 (68.1–72.9) 66.6 (63.6–69.4) 68.8 (66.9–70.6)
23. 1+ hospitalization or 2+ outpatient 79.3 (77.1–81.5) 55 (52.1–58.0) 67.7 (65.3–70.0) 69.1 (66.0–72.2) 68.3 (66.4–70.1)
24. 1+ hospitalization or 1+ outpatient 82.2 (80.1–84.3) 50.4 (47.5–53.4) 66.3 (64.0–68.6) 70.4 (67.2–73.7) 67.7 (65.8–69.6)
Most Inclusive Diagnosis Codes
25. 1+ hospitalization 74 (71.6–76.4) 62 (59.2–64.9) 69.8 (67.4–72.2) 66.8 (63.9–69.7) 68.6 (66.6–70.4)
26. 1+ hospitalization or 2+ outpatient 86.5 (84.7–88.4) 35.3 (32.5–38.2) 61.4 (59.1–63.6) 68.8 (65.1–72.6) 63.2 (61.2–65.1)
27. 1+ hospitalization or 1+ outpatient 90.1 (88.4–91.7) 27.6 (24.9–30.2) 59.7 (57.4–61.8) 70 (65.7–74.4) 61.5 (59.6–63.5)
  1. 95% CI bootstrapped 95% confidence intervals, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, A accuracy