- Study protocol
- Open Access
- Open Peer Review
Decentralizing the delivery of HIV pre-exposure prophylaxis (PrEP) through family physicians and sexual health clinic nurses: a dissemination and implementation study protocol
- Malika Sharma1, 2, 3,
- Allison Chris4,
- Arlene Chan5,
- David C. Knox2,
- James Wilton6,
- Owen McEwen7,
- Sharmistha Mishra1, 2, 8, 9, 10,
- Daniel Grace11,
- Tim Rogers12,
- Ahmed M. Bayoumi2, 8, 9, 13,
- John Maxwell14,
- Rita Shahin4,
- Isaac Bogoch2, 15,
- Mark Gilbert16 and
- Darrell H. S. Tan1, 2, 8, 9, 15Email author
© The Author(s). 2018
- Received: 17 October 2017
- Accepted: 25 June 2018
- Published: 3 July 2018
Gay, bisexual and other men who have sex with men (gbMSM) in Canada continue to experience high rates of incident HIV. Pre-exposure prophylaxis (PrEP, the regular use of anti-HIV medication) reduces HIV acquisition and could reduce incidence. However, there are too few physicians with expertise in HIV care to meet the projected demand for PrEP. To meet demand and achieve greater public health impact, PrEP delivery could be ‘decentralized’ by incorporating it into front-line prevention services provided by family physicians (FPs) and sexual health clinic nurses.
This PrEP decentralization project will use two strategies. The first is an innovative knowledge dissemination approach called ‘Patient-Initiated CME’ (PICME), which aims to empower individuals to connect their family doctors with online, evidence-based, continuing medical education (CME) on PrEP. After learning about the project through community agencies or social/sexual networking applications, gbMSM interested in PrEP will use a uniquely coded card to access an online information module that includes coaching on how to discuss their HIV risk with their FP. They can provide their physician a link to the accredited CME module using the same card. The second strategy involves a pilot implementation program, in which gbMSM who do not have a FP may bring the card to designated sexual health clinics where trained nurses can deliver PrEP under a medical directive. These approaches will be evaluated through quantitative and qualitative methods, including: questionnaires administered to patients and physicians at baseline and at six months; focus groups with patients, FPs, and sexual health clinic staff; and review of sexual health clinic charts. The primary objective is to quantify the uptake of PrEP achieved using each decentralization strategy. Secondary objectives include a) characterizing barriers and facilitators to PrEP uptake for each strategy, b) assessing fidelity to core components of PrEP delivery within each strategy, c) measuring patient-reported outcomes including satisfaction with clinician-patient relationships, and d) conducting a preliminary costing analysis.
This study will assess the feasibility of a novel strategy for disseminating knowledge about evidence-based clinical interventions, and inform future strategies for scale-up of an underutilized HIV prevention tool.
- HIV pre-exposure prophylaxis
- Task shifting
- Implementation science
- Knowledge translation
- HIV prevention
- Men who have sex with men
- Medical education
- Task shifting
PrEP and HIV prevention
Despite decades of prevention efforts centered around behaviour change and condom use, Canada continues to see high rates of HIV acquisition, with approximately 2000 new infections a year since 2002 . A disproportionate burden of infections occurs among gay, bisexual and other men who have sex with men (gbMSM), who make up 49.3% of incident HIV infections and have a 131-fold higher risk of HIV than other Canadian men . The high cost of HIV treatment and care , the young age of those newly diagnosed (mean age 35.8) , and the stigma associated with HIV [5, 6] underscore the economic and social importance of preventing new infections.
To address these challenges, there is increasing interest in HIV pre-exposure prophylaxis (PrEP) as part of a combination approach to controlling the epidemic, together with behavioural, psychosocial and other biomedical approaches. PrEP refers to regular use of tenofovir disoproxil fumarate and emtricitabine (TDF/FTC) by uninfected persons at ongoing HIV risk to prevent HIV acquisition. Clinical trials and observational studies in gbMSM and transgender women show that daily PrEP decreases HIV risk by up to 99% when adherence is high [7–10]. Daily oral TDF/FTC was licensed for use as PrEP in the United States in July 2012, and approved for this indication by Health Canada in February 2016.
While PrEP is not yet used widely in Canada, several factors suggest that PrEP availability and demand are poised to increase dramatically, especially following recent regulatory approval. Interest in PrEP rose from 33.3% in 2010 to 52.5% in 2015 among gbMSM receiving anonymous HIV testing at a Toronto STI clinic [11–14]. In addition, an expert advisory committee has recommended reimbursement of PrEP by public drug plans, which would facilitate wider access . Furthermore, the availability of cost-reduced generic versions of TDF/FTC has greatly increased access to PrEP, although universal coverage has not been achieved.
Current limitations in PrEP provision
The potential increase in PrEP demand offers a timely opportunity to determine how best to deliver PrEP at scale to at-risk populations. In Canada, PrEP has mainly been prescribed in a ‘centralized’ fashion, by a limited number of specialist physicians with expertise in antiretroviral medications and HIV care. However, there are not nearly enough such physicians to meet the anticipated demand for PrEP. For example, in the first 48 h of recruiting gbMSM into PREPARATORY-5, Canada’s only PrEP demonstration project, study coordinators received 92 referrals for the project’s 50 slots .
Physician knowledge about PrEP remains low in Canada . In 2013, a Canadian survey of infectious diseases (ID), HIV primary care, public health and internal medicine physicians demonstrated that 81% of respondents felt it should be possible for PrEP to be prescribed by any doctor, yet only 46.8% felt they themselves had enough knowledge to make informed prescribing decisions . A similar study of North American ID physicians identified “not knowing enough about” PrEP as a reason for not prescribing PrEP . Although PrEP knowledge has been disseminated to community members through community-based agencies, to date the only systematic effort to disseminate knowledge about PrEP to Canadian family doctors has been the publication of a Canadian guideline in November 2017 . In addition, although PrEP could be provided by existing HIV specialists, reliance on specialists is costly and less accessible. A feasible and sustainable approach to decentralized PrEP delivery may help re-allocate HIV specialist time to the care for persons living with HIV and improve primary care provider capacity.
To sustainably and efficiently deliver PrEP to high-risk gbMSM at the scale needed to achieve public health impact, we posit that PrEP delivery should be decentralized by harnessing the skills of family physicians (FPs) and sexual health clinic nurses. As a first step towards this vision, this study will determine the feasibility of two corresponding strategies, each aimed at adapting PrEP delivery to these different providers and healthcare settings, as part of a unique patient-initiated approach.
Engaging family physicians (FPs) in PrEP delivery
PrEP, like other evidence-based primary prevention strategies against chronic diseases, fits within the scope of primary care practice. Surveys of HIV specialists and non-specialists suggest that most providers feel primary care is the appropriate setting for PrEP delivery . A few qualitative studies provide insights into how to achieve the goal of improving capacity among FPs to prescribe PrEP. In interviews with New York City FPs and HIV specialists, a key concern was the risk of “patient mismanagement” by FPs due to inadequate knowledge, implying that PrEP training materials must be rigorously developed and that monitoring of fidelity to the core components of PrEP delivery is crucial . Evidence also suggests that some FPs may have only limited comfort and skill to discuss sexual activity, which is essential to appropriately prescribe PrEP [20, 21]. Literature on physician behaviour shows that clinicians’ motivations to learn about and integrate a new intervention into their practice are greatest when the request comes directly from one of their patients or when there is professional guidance, such as guidelines from normative bodies [21, 22].
While PrEP users may be identified by their providers, public health units using STI data, or by patients themselves, experience suggests that thus far, most individuals initiating PrEP in Canada have been self-identified. In part this is a function of rising knowledge and interest in PrEP at the community level. By encouraging patients to use standardized, self-completed screening tools as a catalyst for discussing their HIV prevention needs with their providers, this project capitalizes on the current situation by harnessing these large patient numbers to disseminate information about PrEP to providers.
Engaging sexual health clinic nurses in PrEP delivery
Ontario’s Ministry of Health and Long-Term Care mandates that public health units provide services to reduce the burden of sexually transmitted infections (STIs) and blood-borne infections, including HIV . Public health units operationalize this mandate by running sexual health clinics staffed primarily by nurses, a model replicated in most of Canada. These clinics already offer a slate of biomedical and behavioural HIV prevention interventions like counseling and STI management. PrEP delivery fits squarely within the mandate of such clinics. PrEP delivery can be readily managed by trained nurses in these settings for several reasons. PrEP has a favourable tolerability and toxicity profile, most users lack comorbidities that would necessitate specialist care and PrEP follow-up can be highly protocolized . Most concomitant issues addressed during PrEP clinic visits relate to public health nurses’ existing expertise, including STIs, vaccinations, and safer sex counseling. Further, this delivery setting may be more acceptable than HIV specialists’ offices since it is community-based, and may alleviate concerns about being misconstrued as an ‘HIV patient’. In Ontario, as in other Canadian jurisdictions, physicians may delegate clinical tasks to other trained providers under a medical directive . Labour market costs for nurses are less than for specialist physicians, and nurses are routinely involved in decentralized strategies for post-exposure prophylaxis (PEP) . Furthermore, many individuals may be unwilling to approach their FP about their sexual health, as Canadian data suggests that nearly 50% of gbMSM are not “out” to their FPs, rendering it vital to offer alternative venues to access sexual health interventions like PrEP .
a dissemination intervention, where patients are empowered to link their FPs with online continuing medical education (CME) about PrEP using an innovative ‘Patient-Initiated CME’ (PICME) approach to knowledge translation, as well as
an implementation intervention, where ‘nurse-led PrEP’ will be piloted in two sexual health clinics operated by Toronto public health under a medical directive.
To characterize the barriers and facilitators to PrEP uptake achieved by each decentralization strategy
To assess fidelity to core components of PrEP delivery within each decentralization strategy as well as mediators of fidelity including accurate knowledge about PrEP among providers. Core components of PrEP delivery include a) identifying a clinical indication for PrEP at each visit, b) ascertainment of HIV negative status prior to each prescription, c) correct prescription of daily oral TDF/FTC, d) monitoring for renal and bone toxicity, and e) STI screening, based on existing guidelines .
To measure patient-reported outcomes including satisfaction with clinician-patient relationship
This project includes multiple components, as outlined in Fig. 1. These are best understood using a step-wise approach. In the first step, a gbMSM becomes interested in PrEP through one of two mechanisms. First, we have built a network of 23 community-based organization (CBO) partners in the Toronto area serving a wide cross-section of gbMSM . These partners will disseminate information cards about the project to their clients. Second, we will post an electronic version of the information card on social/sexual networking apps. Both strategies were successfully used in the past to recruit to our PrEP trial .
In the second step, a potential participant obtains a uniquely coded information card about the project. The card will contain a link to an online patient module on one side, and a link to an accredited CME physician module on the reverse. The unique code will be required for both patients and providers to access the modules, permitting tracking of card distribution and linking of patient/provider responses.
The third step involves completion of the online patient information module, which will describe PrEP, the PICME principle, and project objectives in accessible language, and contain an HIV risk self-assessment tool based on validated HIV risk indices that can be used to catalyze discussions with their clinicians [29, 30]. The module will also coach users on discussing sexual behaviour and HIV risk with clinicians. This content has been developed in partnership with local gbMSM organizations, using principles of patient engagement and agency over one’s own health . Further, because lack of medication coverage is an important potential barrier to PrEP uptake in this population, contact information for an existing ‘PrEP access counsellor’ at a major local AIDS service organization who can assist gbMSM in identifying and navigating drug insurance options will be provided within the module. Finally, the module includes a baseline questionnaire about demographics, sexual behaviour, and patient-provider relationship characteristics.
Fourth, patients with an existing FP will bring the information card to an appointment and use it to initiate a discussion about HIV risk and the appropriateness of using PrEP. In step 5a, physicians may then use the unique code to access the 60-min CME module on PrEP. This module was specifically developed by our team to train FPs unfamiliar with PrEP to provide appropriate PrEP care. A systematic review has demonstrated that 77% of internet-based CME interventions across a variety of domains were found to improve or maintain physician performance . The web-based CME module format minimizes costs, fosters sustainability and matches the preferences of our target audience: in our nationwide survey of physicians, 84.1% indicated that online modules were a preferred format for learning more about PrEP . The module will include a short survey regarding practice demographics, PrEP knowledge and beliefs, and HIV-associated stigma, as there is evidence to suggest that individuals seeking PrEP face stigma pertaining to sexual behaviours, practices, and HIV risk factors .
To help users assess mastery of the clinical material, we have included an end-of-module quiz based on best practices in assessment and evaluation. The literature suggests using case-based multiple choice and short answer formats related to the core components of the PrEP intervention are more indicative of performance than perceived self-assessment . In addition, case-based learning can be authentic as more high-fidelity forms of simulation in medical education, and multiple-choice question formats have been shown to be predictive of clinicians’ performance in practice [34–36]. End-of-module quiz performance will be recorded.
To accommodate users who do not have a FP or are not comfortable approaching their FP despite the coaching within the patient module, users may alternatively bring their coded information postcards to one of two sexual health clinics operated by Toronto Public Health. Nurses at each site will be trained to deliver PrEP under a medical directive through in-person teaching sessions, supplemented by the same evidence-based CME modules used for family physicians. Informed consent for the prospective collection of clinic data will be sought from patients at their first visit, and the unique ID codes will allow linkage with patient data.
In the final step, it is hoped that the FP or public health nurse will initiate PrEP if indicated. We will track this outcome by triangulating data from electronic patient and provider questionnaires at baseline and at 6-months, and from TPH charts.
Participants for this study will be recruited through advertisements on a social/sexual networking applications as well as a network of 23 CBOs, where staff will distribute information cards to gbMSM clients. CBOs will be asked to specifically target individuals meeting the following criteria: identify as gbMSM, are believed to be HIV-uninfected, are interested in or appropriate for PrEP (in their own opinion or in the opinion of the CBO staff), and are a resident in the Greater Toronto Area. Participants will need to be able to understand English to complete the online modules.
Online modules will be launched in September 2017, with data collection taking place over the subsequent 18 months (12 months accrual and final survey at 6 months).
Sample size considerations
This study will involve both quantitative and qualitative data sources. The online learning platform hosting our learning modules allows tracking of logins and quiz scores.
The patient baseline questionnaire will cover demographic characteristics, sexual history, sexual behaviour (including validated HIV risk indices), PrEP knowledge and engagement in healthcare. Those with a FP will also evaluate their doctor-patient relationship using a previously tested Physician-Patient Relationship Quality scale addressing general communication, participatory decision-making processes, willingness to recommend their provider to a friend seeking PrEP and overall satisfaction . These domains will be re-assessed at the 6-monthly follow-up questionnaires, with the addition of questions regarding the outcome of their attempts to obtain PrEP (if any) and identified barriers or facilitators to accessing PrEP through this mechanism. Users will enter their unique code to login, allowing linkage of patient and provider data.
Similarly, the physician baseline questionnaire will capture demographic characteristics, practice characteristics, PrEP knowledge, and opinions regarding PrEP. Questions regarding PrEP knowledge and attitudes will be drawn from prior surveys conducted by our group and others, to facilitate comparison between studies [11, 17, 18, 40]. To characterize physician attitudes towards HIV risk behaviours (eg. condomless sex), a modified version of the Healthcare Provider HIV/AIDS Stigma Scale (HPASS) will be administered . These issues will all re-assessed at the 6-monthly follow-up questionnaires, with the addition of questions regarding whether PrEP was initiated in the index patient (and/or others), questions about perceived barriers/facilitators to PrEP prescribing, and repeat assessment of PrEP knowledge.
Prospective data collection from TPH clinic charts will include information on sexual behaviour, laboratory test results and adverse events. The existing TPH appointment scheduling system will be used to track appointments electronically.
We will also obtain qualitative data through a series of separate focus groups for FPs, sexual health clinic nurses/staff, and patients. Focus groups allow for dynamic exchanges between study participants as people share insights from their lived experience and have opportunities to build on one another’s comments. Participants will be drawn from the pool of questionnaire respondents who indicate willingness to join focus groups using a purposive sampling approach. Efforts will be made to include a range of opinions (eg. positive and negative experiences, demographic diversity), based on preliminary analysis of questionnaires. Focus groups will be digitally audiotaped, transcribed verbatim, and reviewed for accuracy. Notes will also be taken during focus groups to capture key insights that emerge regarding group dynamics and key areas of interest. The focus for inquiry will be facilitators and barriers to each component of the two decentralization strategies, including unintended consequences of the approach. We will also explore the perceived impact of the dissemination and implementation interventions on clinician-patient relationships.
A preliminary costing estimate per patient initiated on PrEP will be conducted from the public payer perspective and including both fixed (program) costs and variable (per-individual) costs. We will estimate program costs by estimating additional administration and overhead costs at public health clinics, public health laboratory wholesale purchase costs for test kits and technician time, and costs for the online learning platform. We do not anticipate substantial additional administrative costs at FP offices, since each physician will likely see only a few patients on average. Costs for each individual initiating PrEP will be estimated using a unit cost approach, in which we will estimate the average number of units in each of the following categories and assign each a corresponding cost. Categories include: physician visits for both primary and specialty care (costs from provincial fee schedules), pharmacy administration fees (costs from markup rates), public health costs for nursing staff (costs estimated from labour market rates), and drug costs (costs estimated from publicly available list prices). Because public insurers may negotiate lower drug prices than the list price, we will perform sensitivity analyses across a range of cost deflators. We will also estimate drug costs paid for by patients out-of-pocket and by private insurers. Additional costs will be drawn from the published literature using Canadian data wherever possible.
To estimate the relative contribution of the PICME and nurse-led PrEP strategies to PrEP scale-up in Ontario, we will attempt to quantify PrEP uptake province-wide (ie. estimate the denominator for our project’s numerator) in collaboration with the Applied Epidemiology Unit of the Ontario HIV Treatment Network and Public Health Ontario (facilitated by co-Investigator J. Wilton). For example, records from laboratory test requisitions for all HIV tests conducted in Ontario are housed at Public Health Ontario, and efforts are currently underway to revise the HIV serology requisition to add a “PrEP” checkbox as a reason for testing. Since confirmation of HIV negative status is a core component of PrEP delivery, if added, this requisition change would provide a convenient way to estimate the total number of PrEP users in Ontario (after adjustment for the current non-completion rates of ~ 37% in current ‘reason for testing’ data [M Gilbert, personal communication]). The CME module will include explicit instructions to mark this checkbox on the updated requisitions.
Since a potential unintended consequence of our work may be an increase in specialist referrals, team members running large PrEP clinics in Toronto will quantify referrals received during and 24 month before the study period using clinic administrative data.
Cascade of steps involved in PrEP uptake and corresponding data sources
Number of cards distributed
Number of e-card impressions
Patient initiates module
Number of unique codes used to login
Online learning management platform (see section 5.2)
Patient completes online patient module
Number of codes/logins reaching end of patient module
Patient brings postcard to family physician
Number of patients who initiate PrEP discussion with physician
Patient self-report on follow-up questionnaire (section 5.2)
FP initiates CME
Number of unique codes used to login
Online learning management platform
FP completes CME
Number of codes/logins reaching end of module quiz/certificate
Physician prescribes PrEP
Number of patients provided PrEP prescription by family physician
Patient and physician follow-up questionnaires
Patient brings postcard to sexual health clinic
Number of patients who approach TPH for an initial PrEP appointment
Patient self-report on follow-up questionnaire
Patient attends sexual health clinic appt.
Number of appointments booked
TPH Appointment Scheduling System
Number of appointments attended
Nurse prescribes PrEP
Number of patients provided PrEP prescription by TPH nurse
TPH patient charts
We will use a variety of analyses to assess our secondary objectives. To characterize barriers and facilitators to PrEP uptake in each decentralization strategy, we will use descriptive statistics to summarize questionnaire responses, impact on TPH clinics, and specialist referrals. We will construct two logistic regression models to explore the association between patient and physician characteristics (predictors) with module uptake and with PrEP uptake (outcomes). Key predictors of interest include practice type, identification as an HIV specialist and HIV related stigma for physicians and household income, language, sexual practices and previous STI for patients. We will supplement these quantitative findings with content analysis of open-ended questionnaire responses and transcribed focus group discussions. We will use a coding approach that involves the input of community members through a Community Advisory Board, with the goal of developing a conceptual framework to understand barriers and facilitators of this approach .
To assess fidelity we will conduct chart reviews of the sexual health clinic patients to assess adherence to the core components of PrEP delivery, such as clinical indication for PrEP, documentation of HIV seronegativity, correct PrEP prescription, toxicity monitoring, and appropriate STI screening. Because of the impracticality of conducting chart reviews at FP offices, we will rely on indirect measures of fidelity for the PICME strategy data from patient and provider follow-up questionnaires. Such measures will include confirmation of whether modules were completed, follow-up appointments were scheduled following initial presentation of the card, and whether PrEP was ultimately prescribed. We will also explore provider-level correlates of fidelity (eg. practice characteristics, questionnaire responses including HPASS scale,71 CME quiz scores) in univariable (chi square) and multivariable (logistic regression) analyses as appropriate.
Finally, we will summarize patient-reported outcomes including satisfaction with clinician-patient relationship using a previously validated Physician-Patient Relationship Quality scale. This scale has demonstrated high levels of internal consistency (Cronbach’s alpha 0.81–0.93) when used in a sample composed primarily of HIV-infected MSM .
Ethics and consent to participate
This study has been approved by the St. Michael’s Hospital (REB #16–348) and Toronto Public Health (REB #2016–16) Research Ethics Boards. An electronic informed consent process will be used for the collection of patient and physician questionnaire data, and additional in-person informed consent processes will be used to obtain consent for the review of sexual health clinic charts and for the focus groups.
Information collected during this study will be recorded using the unique identifying code provided to potential participants on the distributed card/e-card. A master linking log, used for the purposes of 6-month follow-up and targeted focus group sampling, will be used to link email addresses to unique identifiers. The log book will be kept locked on site. Only de-identified data will be recorded on all other study documents.
A major impediment to broader PrEP rollout in Canada is the lack of accessible, knowledgeable primary care clinicians who can prescribe PrEP without relying on costly and limited specialists. This implementation science project addresses this challenge, and our findings will inform future PrEP scale-up efforts.
Although FPs have access to large numbers of at-risk, HIV-negative persons, and may have expertise with other components of a combination HIV prevention approach like counselling and addressing substance use and mental health concerns, many may be uncomfortable prescribing PrEP since it involves an antiretroviral drug. The PICME project partly addresses this “purview paradox,” which speaks to the urgent need to build capacity in this group [21, 43].
In addition, this study pilots nurse-led PrEP at two of the four sexual health clinics operated by Toronto Public Health, gathering detailed contextual information on effectiveness and scalability. This data can address some of the challenges involved in nurse-led PrEP, as longitudinal patient follow-up is a departure from the usual model of episodic STI care used in sexual health clinics . From a health policy perspective, and as recommended by the World Health Organization, this intervention represents ‘task-shifting’ . By providing extensive training to the nurses, basing the medical directive on evidence-based Canadian guidelines , and ensuring the availability of specialist consultation (as will be provided to FPs), this model is also a form of inter-professional mentorship and collaboration that optimizes the scope of practice of each health professional .
By quantifying the impact of the PICME and nurse-led PrEP strategies in our primary analysis, we will ascertain the feasibility and effectiveness of both strategies in increasing PrEP uptake. In addition, we will learn which steps and stakeholders pose the greatest challenges to increased uptake as a means of understand how best to approach future PrEP scale-up. Finally, our costing analyses, in conjunction with our data on clinical outcomes and sexual behaviour, will be used in mathematical models of HIV transmission to evaluate population-level PrEP implementation strategies and impact across Canada.
The study is firmly rooted in the implementation science paradigm outlined in Fig. 2. Using the definition of MacLean, Rabin and others, the proposed ‘PICME’ intervention is a dissemination activity - “an active approach of spreading evidence-based interventions to the target audience via determined channels using planned strategies” [46, 47]. Here, PrEP is the evidence-based clinical intervention, FPs represent the well-defined target audience, and patients seeking PrEP are the pre-determined channels who can help disseminate PrEP information using a unique strategy (PICME). Using a definition by Proctor, the proposed nurse-led PrEP intervention is an implementation activity, since it involves “the process of putting to use, or integrating, evidence-based interventions within a specific setting” .
This study has some limitations. Over the course of the study period, PrEP use may increase outside of PICME or nurse-led intervention, which may result in fewer participants going through the PICME process. However, it may also result in increased interest in guideline-based CME on PrEP. The use of time-series analysis may be done to address such secular trends should they occur. Diffusion effects into the community and among health-care providers may also occur, which may also decrease the number of subsequent participants going through all steps in the PICME process. In addition, more than one patient may present any given FP with the card. While this will decrease the number of linked patient-provider surveys, data on the number of patients approaching a provider will be gleaned through 6-month surveys and focus groups.
Ultimately, the decentralizing of PrEP delivery, when nested in a combination of biomedical and behavioural HIV prevention strategies, has the potential to dramatically decrease HIV incidence. Data from the Kaiser Permanente health system in San Francisco has shown zero new infections since 2012 with increasing PrEP use in a large clinical practice setting serving large numbers of MSM . Similarly, the ‘Demo Project’ observed an extremely low HIV incidence of 0.43 (95%CI = 0.05–1.54) when delivering PrEP in three community-based practice settings in the United States . However, neither of these studies explicitly evaluated knowledge dissemination and implementation outcomes as we will. Our work will gather key data to inform the scale-up of new PrEP dissemination and implementation strategies in the context of our specific target population, healthcare system, and social context.
This study was funded by the Academic Health Sciences Centre (AHSC) Alternate Funding Plan (AFP) Innovation Fund and the Canadian Institutes of Health Research (CIHR). Neither funding body was involved in the design of the study, data collection, data analysis, or manuscript preparation.
Availability of data and materials
The datasets generated and/or analysed during the current study are not publicly available due to issues of participant confidentiality and privacy but are available from the corresponding author on reasonable request.
MS wrote the first draft of this manuscript. AChris, AChan and RS facilitated medical directive for nurse-led PrEP. MS, AChan, TR, DK, and DHST developed the CME module. MS, JW, OM, and DHST developed the patient module for this study. SM and AB assisted with survey development and costing analyses. MS, DG, and DHST developed focus group methodology and guides for data collection. DK facilitated CFPC Mainpro+ approval for physician CME used in this project. JM provided community-based organizational input and assistance with issues around PrEP access. IB will assist with monitoring of PrEP referrals. MG provided expertise and data around PrEP epidemiology in Ontario. All authors reviewed the final manuscript.
Ethics approval and consent to participate
Ethics approval was obtained from the St. Michael’s Hospital Research Ethics Board (REB # 16–348) and the Toronto Public Health Research Ethics Board (File #2016–16). Informed consent to participate is to be obtained from all participants.
Consent for publication
Malika Sharma, Arlene Chan, Sharmistha Mishra, Mark Gilbert, Daniel Grace, Rita Shahin, Isaac Bogoch, Ahmed M. Bayoumi, Tim Rogers, John Maxwell, James Wilton, Owen McEwen and Allison Chris have no competing interests to declare.
Dr. David Knox has consulted for ViiV Health Sciences and received honoraria from Merck and Gilead Sciences.
Dr. Tan reports grants from Canadian Institutes of Health Research & Ontario HIV Treatment Network, during the conduct of the study; grants from Gilead, grants from ViiV Healthcare, and participation in clinical trials sponsored by GSK, outside the submitted work.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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- Public Health Agency of Canada. HIV and AIDS in Canada: Surveillance Report to December 31, 2013. 2014. http://www.phac-aspc.gc.ca/aids-sida/publication/survreport/2013/dec/assets/pdf/hiv-aids-surveillence-eng.pdf.
- Public Health Agency of Canada. Summary: estimates of HIV incidence, prevalence, and proportion undiagnosed in Canada, 2014. 2015. http://www.catie.ca/sites/default/files/2014-HIV-Estimates-in-Canada-EN.pdf.
- Krentz HB, Gill MJ. Cost of medical care for HIV-infected patients within a regional population from 1997 to 2006. HIV Med. 2008;9:721–30.View ArticlePubMedGoogle Scholar
- Remis RS, Liu J. HIV/AIDS in Ontario: preliminary report, 2011. 2013. http://www.ohemu.utoronto.ca/doc/PHERO2011_report_preliminary.pdf.Google Scholar
- Kelly JA, St Lawrence JS, Smith S, Hood HV, Cook DJ. Stigmatization of AIDS patients by physicians. Am J Public Health. 1987;77:789–91.View ArticlePubMedPubMed CentralGoogle Scholar
- Devine PG, Plant EA, Harrison K. The problem of “us” versus “them” and AIDS stigma. Am Behav Sci. 1999;42:1212–28.View ArticleGoogle Scholar
- Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363:2587–99.View ArticlePubMedPubMed CentralGoogle Scholar
- Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367:399–410.View ArticlePubMedPubMed CentralGoogle Scholar
- Thigpen MC, Kebaabetswe PM, Paxton LA, Smith DK, Rose CE, Segolodi TM, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med. 2012;367:423–34.View ArticlePubMedGoogle Scholar
- Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168–74.View ArticlePubMedPubMed CentralGoogle Scholar
- Senn H, Wilton J, Sharma M, Fowler S, Tan DHS. Knowledge of and opinions on HIV preexposure prophylaxis among front-line service providers at Canadian AIDS service organizations. AIDS Res Hum Retrovir. 2013;29:1183–9.PubMedView ArticleGoogle Scholar
- Leonardi M, Lee E, Tan DHS. Awareness of, usage of and willingness to use HIV pre-exposure prophylaxis among men in downtown Toronto, Canada. Int J STD AIDS. 2011;22:738–41.View ArticlePubMedGoogle Scholar
- Wilton J, Kain T, Fowler S, Hart TA, Grennan T, Maxwell J, et al. Use of an HIV-risk screening tool to identify optimal candidates for PrEP scale-up among men who have sex with men in Toronto, Canada: disconnect between objective and subjective HIV risk. J Int AIDS Soc. 2016;19:20777.View ArticlePubMedPubMed CentralGoogle Scholar
- Rana J, Wilton J, Fowler S, Hart TA, Bayoumi AM, Tan DHS. Trends in the awareness, acceptability, and usage of HIV preexposure prophylaxis among at-risk men who have sex with men in Toronto. Can J Public Health. 2018. https://doi.org/10.17269/s41997-018-0064-3.
- Canadian Agency for Drugs and Technologies in Health. CADTH Canadian Drug Expert Committee Final Recommendation: Emtricitabine/Tenofovir disoproxil fumarate Indication: Pre-exposure Prophylaxis of HIV-1 infection. 2016. https://cadth.ca/sites/default/files/cdr/complete/SR0479_complete_Truvada_Aug-26-16.pdf. Accessed 3 May 2016.
- Wilton J, Noor SW, Schnubb A, Lawless J, Hart TA, Grennan T, Fowler S, Maxwell J, Tan DHS. High HIV risk and syndemic burden regardless of referral source among MSM screening for a PrEP demonstration project in Toronto, canada. BMC Public Health. 2018;18(1):292.Google Scholar
- Sharma M, Wilton J, Senn H, Fowler S, Tan DHS. Preparing for PrEP: perceptions and readiness of Canadian physicians for the implementation of HIV pre-exposure prophylaxis. PLoS One. 2014;9:e105283.View ArticlePubMedPubMed CentralGoogle Scholar
- Karris MY, Beekmann SE, Mehta SR, Anderson CM, Polgreen PM. Are we prepped for preexposure prophylaxis (PrEP)? Provider opinions on the real-world use of PrEP in the United States and Canada. Clin Infect Dis Off Publ Infect Dis Soc Am. 2014;58:704–12.View ArticleGoogle Scholar
- Tan DHS, Hull MW, Yoong D, Tremblay C, O’Byrne P, Thomas R, Kille J, Baril JG, Cox J, Giguere P, Harris M, Hughes C, MacPherson P, O’Donnell S, Reimer J, Singh A, Barrett L, Bogoch I, Jollimore J, Lambert G, Lebouche B, Metz G, Rogers T, Shafran S, Biomedical HIV Prevention Working Group of the CIHR Canadian HIV Trials Network. Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis. Can Med Assoc J. 2017;189(47):E1448-E1458.Google Scholar
- Hoffman S, Guidry JA, Collier KL, Mantell JE, Boccher-Lattimore D, Kaighobadi F, et al. A clinical home for Preexposure prophylaxis: Diverse Health Care Providers’ Perspectives on the “Purview Paradox”. J Int Assoc Provid AIDS Care. 2016;15:59–65.View ArticlePubMedGoogle Scholar
- Krakower D, Ware N, Mitty JA, Maloney K, Mayer KH. HIV providers’ perceived barriers and facilitators to implementing pre-exposure prophylaxis in care settings: a qualitative study. AIDS Behav. 2014;18:1712–21.View ArticlePubMedPubMed CentralGoogle Scholar
- Davis DA, Thomson MA, Oxman AD, Haynes RB. Changing physician performance. A systematic review of the effect of continuing medical education strategies. JAMA. 1995;274:700–5.View ArticlePubMedGoogle Scholar
- Ministry of Health and Long-Term Care. Ontario Public Health Standards, 2008. 2017. http://www.health.gov.on.ca/en/pro/programs/publichealth/oph_standards/docs/protocols_guidelines/Ontario_Public_Health_Standards_2018_en.pdf.
- Department of Health and Human Services, Centers for Disease Control and Prevention. Preexposure Prophylaxis for the Prevention of HIV Infection in the United States - 2014 Clinical Practice Guideline. 2014. https://www.cdc.gov/hiv/pdf/prepguidelines2014.pdf.
- College of Physicians and Surgeons of Ontario. Delegation of Controlled Acts: Policy Statement #5–12. 2012.Google Scholar
- O’Byrne P, MacPherson P, Roy M, Kitson C. Overviewing a nurse-led, community-based HIV PEP program: applying the extant literature in frontline practice. Public Health Nurs Boston Mass. 2015;32:256–65.View ArticleGoogle Scholar
- Dulai J, Le D, Ferlatte O, Marchand R, Trussler T. Sex now across Canada. Vancouver, B.C.: community-based research Centre for gay Men’s health; 2015.Google Scholar
- Wilton J, Tan DHS, Maxwell J, Fowler S, Grennan T, Hart T, Li A. Exploring the roles of community-based organizations (CBOs) in the rollout of HIV pre-exposure prophylaxis (PrEP) among Toronto gay, bisexual & other MSM (gbMSM). 24th Canadian Conference on HIV/AIDS Research. Abstract O116. Toronto, Ontario, Canada. Apr 3-May 3, 2015.Google Scholar
- Smith DK, Pals SL, Herbst JH, Shinde S, Carey JW. Development of a clinical screening index predictive of incident HIV infection among men who have sex with men in the United States. J Acquir Immune Defic Syndr 1999. 2012;60:421–7.View ArticleGoogle Scholar
- Menza TW, Hughes JP, Celum CL, Golden MR. Prediction of HIV acquisition among men who have sex with men. Sex Transm Dis. 2009;36:547–55.View ArticlePubMedPubMed CentralGoogle Scholar
- Schneider J, Kaplan SH, Greenfield S, Li W, Wilson IB. Better physician-patient relationships are associated with higher reported adherence to antiretroviral therapy in patients with HIV infection. J Gen Intern Med. 2004;19:1096–103.View ArticlePubMedPubMed CentralGoogle Scholar
- Grace D, Jollimore J, MacPherson P, Strang M, Tan DHS. The PrEP-stigma paradox: learning from Canada’s first wave of PrEP users. Vancouver: B.C.: community-based research Centre for gay Men’s health; 2016.Google Scholar
- Kruger J, Dunning D. Unskilled and unaware of it: how difficulties in recognizing one’s own incompetence lead to inflated self-assessments. J Pers Soc Psychol. 1999;77:1121–34.View ArticlePubMedGoogle Scholar
- LaRochelle JS, Durning SJ, Pangaro LN, Artino AR, van der Vleuten C, Schuwirth L. Impact of increased authenticity in instructional format on preclerkship students’ performance: a two-year, prospective, randomized study. Acad Med J Assoc Am Med Coll. 2012;87:1341–7.View ArticleGoogle Scholar
- Tamblyn R, Abrahamowicz M, Dauphinee WD, Hanley JA, Norcini J, Girard N, et al. Association between licensure examination scores and practice in primary care. JAMA. 2002;288:3019–26.View ArticlePubMedGoogle Scholar
- Norcini JJ, Lipner RS, Kimball HR. Certifying examination performance and patient outcomes following acute myocardial infarction. Med Educ. 2002;36:853–9.View ArticlePubMedGoogle Scholar
- Public Health Agency of Canada. M-Track: Enhanced Surveillance of HIV, Sexually Transmitted and Blood-borne Infections, and Associated Risk Behaviours among Men Who Have Sex with Men in Canada. Phase 1 Report. Centre for Communicable Diseases and Infection Control, Infectious Disease Prevention and Control Branch, Public Health Agency of Canada; 2011. http://librarypdf.catie.ca/pdf/ATI-20000s/26403.pdf. Accessed 5 May 2017.
- Yang Q, Ogunnaike-Cooke S, Halverson J. Estimated national HIV incidence rates among key sub-populations in Canada. 25th Canadian Conference on HIV/AIDS Research. Abstract EPH3.5. Winnipeg, Manitoba, Canada. May 12-15, 2016.Google Scholar
- Naing L, Winn T, Rusli B. Practical issues in calculating the sample size for prevalence studies. Arch Orofac Sci. 2006;1:9–14.Google Scholar
- Yoong D, Naccarato M, Sharma M, Wilton J, Senn H, Tan DH. Preparing for pre-exposure prophylaxis: perceptions and readiness of Canadian pharmacists for the implementation of HIV pre-exposure prophylaxis. Int J STD AIDS. 2016;27:608–16.View ArticlePubMedGoogle Scholar
- Wagner AC, Hart TA, McShane KE, Margolese S, Girard TA. Health care provider attitudes and beliefs about people living with HIV: initial validation of the health care provider HIV/AIDS stigma scale (HPASS). AIDS Behav. 2014;18:2397–408.View ArticlePubMedGoogle Scholar
- Grace D, Chown SA, Jollimore J, Parry R, Kwag M, Steinberg M, et al. HIV-negative gay men’s accounts of using context-dependent sero-adaptive strategies. Cult Health Sex. 2014;Google Scholar
- Krakower D, Mayer KH. Engaging healthcare providers to implement HIV pre-exposure prophylaxis. Curr Opin HIV AIDS. 2012;7:593–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Arnold EA, Hazelton P, Lane T, Christopoulos KA, Galindo GR, Steward WT, et al. A qualitative study of provider thoughts on implementing pre-exposure prophylaxis (PrEP) in clinical settings to prevent HIV infection. PLoS One. 2012;7:e40603.View ArticlePubMedPubMed CentralGoogle Scholar
- World Health Organization. Task shifting: global recommendations and guidelines. 2008. Geneva, Switzerland: World Health Organization; 2008.Google Scholar
- MacLean DR. Positioning dissemination in public health policy. Can J Public Health Rev Can Sante Publique. 1996;87(Suppl 2):S40–3.Google Scholar
- Rabin B, Brownson R. Developing the terminology for dissemination and implementation research. In: Brownson R, Colditz G, Proctor E, editors. Dissemination and implementation research in health. New York: Oxford University Press; 2012.Google Scholar
- Proctor E, Brownson R. Measurement issues in dissemination and implementation research. In: Brownson R, Colditz G, Proctor E, editors. Dissemination and implementation research in health. New York: Oxford University Press; 2012.Google Scholar
- Volk JE, Marcus JL, Phengrasamy T, Blechinger D, Nguyen DP, Follansbee S, et al. No new HIV infections with increasing use of HIV Preexposure prophylaxis in a clinical practice setting. Clin Infect Dis Off Publ Infect Dis Soc Am. 2015;61:1601–3.View ArticleGoogle Scholar
- Liu AY, Cohen SE, Vittinghoff E, Anderson PL, Doblecki-Lewis S, Bacon O, et al. Preexposure prophylaxis for HIV infection integrated with municipal- and community-based sexual health services. JAMA Intern Med. 2016;176:75–84.View ArticlePubMedPubMed CentralGoogle Scholar