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Table 5 Parameters and variables examined in the probabilistic sensitivity analysis. Parameters with varied values

From: Cost-effectiveness of a community-based cardiovascular disease prevention intervention in medically underserved rural areas

Parameter Distribution Mean Range
Outcomes
 BMI reduction Normal 0.71 0.08 1.35 (95% CI of mean)
 Weight loss Normal 1.85 0.16 3.55 (95% CI of mean)
 CRP reduction, mg/L Normal 1.15 0.15 2.16 (95% CI of mean)
 Simple 7 increase Normal 0.67 0.14 1.21 (95% CI of mean)
 Annual ASCVD risk reduction Log normal 0.00096 0.00043 0.00149 (95% CI of mean)
Costs, per person
 Resources of SHHC Υ, gamma 775 581 968 (±25% of mean)
 Resources of SHHC-CON Υ, gamma 667 500 833 (±25% of mean)
 Participant of SHHC Υ, gamma 1087 815 1359 (±25% of mean)
 Participant of SHHC-CON Υ, gamma 887 665 1108 (±25% of mean)
Medical cost, 2013 $
 CHD (nonfatal mi) Υ, gamma 62,200 52,870 71,530 (±15% of mean)
 Stroke (nonfatal) Υ, gamma 20,509 17,433 23,585 (±15% of mean)
 Follow-up visit, 2013 $ Υ, gamma 75 53 98 (±30% of mean)
QALYs
 Women age 55–64, BMI 30–40 β, beta 0.798 0.678 0.918 (±15% of mean)
 CHD β, beta 0.697 0.592 0.802 (±15% of mean)
 Stroke β, beta 0.590 0.502 0.679 (±15% of mean)
  1. The incidence rates are not the assumed CHD or stroke rates for the hypothetical population in the probabilistic sensitivity analysis. The ratio of the two incidence rates is used in the probabilistic sensitivity analysis to partition the reduction of an ASCVD event into a CHD event reduction and a stroke event reduction