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Table 2 Study parameter and ranges in one-way sensitivity analysis

From: Cost-utility analysis of palonosetron in the antiemetic regimen for cisplatin-containing highly emetogenic chemotherapy in Japan

Pramater Values Range Ref
CINV related health state probabilities
 Complete response in acute phase in PALO regimen 0.918 95% CI [7]
 Complete response in delayed phase in PALO regimen 0.672 95% CI [7]
 Complete response in acute phase in GRA regimen 0.918 95% CI [7]
 Complete response in delayed phase in GRA regimen 0.591 95% CI [7]
Costs JPY (USD) JPY (USD)  
 Palonosetron 0.75 mg (IV) 14,972 (133.5) 7,486-14,972 (66.7-133.5) [15]
 Granisetoron 1 mg (IV) 1,273 (11.3) 590 -1,273 (5.26-11.3) [15]
 Aprepitantcapusule set (125 mg /80 mg /80 mg) (PO) 11,638.2 (103.8)   [15]
 Dexametazone 2 mg (IV) 99 (0.883)   [15]
 Dexametazone 4 mg (PO) 34 (0.303)   [15]
 Blood testb 1,580 (14.1)   [16]
 Internal medicine for rescue medication for PALO regimen 432 (3.85) ± 30% [15, 18, 19]
 Internal medicine for rescue medication for GRA regimen 5,956.5 (53.1) ± 30% [15, 18, 19]
 Infusion therapy for rescue medication 1,374 (12.3) ± 30% [15, 16, 18, 19]
 Total cost per acute CINV in PALO regimen 432 (3.85)   
 Total cost per delayed CINV in PALO regimen 2,396 (21.36)   
 Total cost per acute CINV in GRA regimen 5,956.5 (53.10)   
 Total cost per delayed CINV in GRA regimen 10,221 (91.12)   
Utility values
 Complete protection 0.9 ± 30% [13, 14, 20,21,22]
 Complete response at best 0.7 ± 30% [13, 14, 20,21,22]
 Incomplete response 0.2 ± 30% [13, 14, 20,21,22]
  1. CINV Chemotherapy induced nausea and vomitingn, PALO Palonosetron, GRA Granisetron, CI Confidence interval, JPY Japanese yen, IV Intravenous, PO Oral. Exchange rate, 1 USD = 112.17 JPY